| Literature DB >> 18400535 |
Caroline Brorsson1, Regine Bergholdt, Marketa Sjögren, Stefanie Eising, Karina Meden Sørensen, David M Hougaard, Marju Orho-Melander, Leif Groop, Flemming Pociot.
Abstract
Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1D), making this gene an interesting T1D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1D could not be demonstrated.Entities:
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Year: 2008 PMID： 18400535 DOI： 10.1016/j.ymgme.2008.02.011
Source DB: PubMed Journal: Mol Genet Metab ISSN： 1096-7192 Impact factor: 4.797