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Literature DB >> 19092925

Sensing voltage across lipid membranes.

Abstract

The detection of electrical potentials across lipid bilayers by specialized membrane proteins is required for many fundamental cellular processes such as the generation and propagation of nerve impulses. These membrane proteins possess modular voltage-sensing domains, a notable example being the S1-S4 domains of voltage-activated ion channels. Ground-breaking structural studies on these domains explain how voltage sensors are designed and reveal important interactions with the surrounding lipid membrane. Although further structures are needed to understand the conformational changes that occur during voltage sensing, the available data help to frame several key concepts that are fundamental to the mechanism of voltage sensing.

Entities: Chemical Disease Gene Mutation Species

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Year: 2008 PMID： 19092925 PMCID： PMC2629456 DOI： 10.1038/nature07620

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

86 in total

1. The size of gating charge in wild-type and mutant Shaker potassium channels.

Authors: N E Schoppa; K McCormack; M A Tanouye; F J Sigworth
Journal: Science Date: 1992-03-27 Impact factor: 47.728

2. Molecular model of the action potential sodium channel.

Authors: H R Guy; P Seetharamulu
Journal: Proc Natl Acad Sci U S A Date: 1986-01 Impact factor: 11.205

Review 3. Molecular properties of voltage-sensitive sodium channels.

Authors: W A Catterall
Journal: Annu Rev Biochem Date: 1986 Impact factor: 23.643

4. Primary structure and functional expression of a mouse inward rectifier potassium channel.

Authors: Y Kubo; T J Baldwin; Y N Jan; L Y Jan
Journal: Nature Date: 1993-03-11 Impact factor: 49.962

5. Primary structure of the receptor for calcium channel blockers from skeletal muscle.

Authors: T Tanabe; H Takeshima; A Mikami; V Flockerzi; H Takahashi; K Kangawa; M Kojima; H Matsuo; T Hirose; S Numa
Journal: Nature Date: 1987 Jul 23-29 Impact factor: 49.962

6. Expression of functional sodium channels from cloned cDNA.

Authors: M Noda; T Ikeda; H Suzuki; H Takeshima; T Takahashi; M Kuno; S Numa
Journal: Nature Date: 1986 Aug 28-Sep 3 Impact factor: 49.962

7. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila.

Authors: B L Tempel; D M Papazian; T L Schwarz; Y N Jan; L Y Jan
Journal: Science Date: 1987-08-14 Impact factor: 47.728

8. Direct physical measure of conformational rearrangement underlying potassium channel gating.

Authors: L M Mannuzzu; M M Moronne; E Y Isacoff
Journal: Science Date: 1996-01-12 Impact factor: 47.728

9. Evidence for voltage-dependent S4 movement in sodium channels.

Authors: N Yang; R Horn
Journal: Neuron Date: 1995-07 Impact factor: 17.173

10. Electrostatic interactions of S4 voltage sensor in Shaker K+ channel.

Authors: D M Papazian; X M Shao; S A Seoh; A F Mock; Y Huang; D H Wainstock
Journal: Neuron Date: 1995-06 Impact factor: 17.173

159 in total

Review 1. Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis.

Authors: Norman J Haughey; Veera V R Bandaru; Mihyun Bae; Mark P Mattson
Journal: Biochim Biophys Acta Date: 2010-05-07

Review 2. Sphingolipids in neurodegeneration.

Authors: Norman J Haughey
Journal: Neuromolecular Med Date: 2010-08-25 Impact factor: 3.843

Sensing voltage across lipid membranes.

1. The size of gating charge in wild-type and mutant Shaker potassium channels.

2. Molecular model of the action potential sodium channel.

Review 3. Molecular properties of voltage-sensitive sodium channels.

4. Primary structure and functional expression of a mouse inward rectifier potassium channel.

5. Primary structure of the receptor for calcium channel blockers from skeletal muscle.

6. Expression of functional sodium channels from cloned cDNA.

7. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila.

8. Direct physical measure of conformational rearrangement underlying potassium channel gating.

9. Evidence for voltage-dependent S4 movement in sodium channels.

10. Electrostatic interactions of S4 voltage sensor in Shaker K+ channel.

Review 1. Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis.

Review 2. Sphingolipids in neurodegeneration.

3. Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier.

4. Forward genetic analysis reveals multiple gating mechanisms of TRPV4.

5. Principles of conduction and hydrophobic gating in K+ channels.

6. Zinc inhibition of monomeric and dimeric proton channels suggests cooperative gating.

7. Contribution of the S5-pore-S6 domain to the gating characteristics of the cation channels TRPM2 and TRPM8.

Review 8. Mechanisms of closed-state inactivation in voltage-gated ion channels.

9. Accommodation of a central arginine in a transmembrane peptide by changing the placement of anchor residues.

10. Membrane Potential Distinctly Modulates Mobility and Signaling of IL-2 and IL-15 Receptors in T Cells.