Mário L R Monteiro1, André L F Portes2, Frederico C Moura2, Dina B W Regensteiner2. 1. Department of Ophthalmology and Otolaryngology, University of São Paulo Medical School, São Paulo, Brazil. mlrmonteiro@terra.com.br. 2. Department of Ophthalmology and Otolaryngology, University of São Paulo Medical School, São Paulo, Brazil.
Abstract
PURPOSE: to test the ability of frequency-doubling technology (FDT) perimetry to detect dysthyroid optic neuropathy (DON). METHODS: Fifteen eyes of 15 patients with DON and 15 healthy control eyes were studied. Eligible eyes had a diagnosis of DON based on visual field abnormalities on standard automated perimetry and had visual acuity better than 20/30. FDT testing was performed using both the C-20-5 screening test and the C-20 full-threshold test. Normal and DON eyes were compared with regard to FDT mean sensitivity. RESULTS: Sensitivity ranges were 40.0%-86.7% for the screening test, and 53.3%-100.0% (total deviation) and 20.0-93.3 (pattern deviation) for the C-20 threshold test. The corresponding specificity ranges were 86.7-100.0, 33.3-93.3, and 26.7-100.0, respectively. The best sensitivity/specificity ratios were for one abnormal point depressed <5% in the screening test (86.7%/86.7%), one point depressed <1% in the total deviation analysis (80.0%/86.7%), and one point depressed <2% in the pattern deviation analysis (80.0%/86.7%). DON eyes presented significantly lower than normal average sensitivity in the central, pericentral, and peripheral areas. CONCLUSIONS: FDT perimetry is a useful screening tool for DON in eyes with normal or only slightly reduced visual acuity.
PURPOSE: to test the ability of frequency-doubling technology (FDT) perimetry to detect dysthyroid optic neuropathy (DON). METHODS: Fifteen eyes of 15 patients with DON and 15 healthy control eyes were studied. Eligible eyes had a diagnosis of DON based on visual field abnormalities on standard automated perimetry and had visual acuity better than 20/30. FDT testing was performed using both the C-20-5 screening test and the C-20 full-threshold test. Normal and DON eyes were compared with regard to FDT mean sensitivity. RESULTS: Sensitivity ranges were 40.0%-86.7% for the screening test, and 53.3%-100.0% (total deviation) and 20.0-93.3 (pattern deviation) for the C-20 threshold test. The corresponding specificity ranges were 86.7-100.0, 33.3-93.3, and 26.7-100.0, respectively. The best sensitivity/specificity ratios were for one abnormal point depressed <5% in the screening test (86.7%/86.7%), one point depressed <1% in the total deviation analysis (80.0%/86.7%), and one point depressed <2% in the pattern deviation analysis (80.0%/86.7%). DON eyes presented significantly lower than normal average sensitivity in the central, pericentral, and peripheral areas. CONCLUSIONS: FDT perimetry is a useful screening tool for DON in eyes with normal or only slightly reduced visual acuity.
Authors: David McKeag; Carol Lane; John H Lazarus; Lelio Baldeschi; Kostas Boboridis; A Jane Dickinson; A Iain Hullo; George Kahaly; Gerry Krassas; Claudio Marcocci; Michele Marinò; Maarten P Mourits; Marco Nardi; Christopher Neoh; Jacques Orgiazzi; Petros Perros; Aldo Pinchera; Susanne Pitz; Mark F Prummel; Maria S Sartini; Wilmar M Wiersinga Journal: Br J Ophthalmol Date: 2006-10-11 Impact factor: 4.638
Authors: Allan C Pieroni Gonçalves; Lucas Nunes Silva; Eloísa M M S Gebrim; Suzana Matayoshi; Mário Luiz Ribeiro Monteiro Journal: Clinics (Sao Paulo) Date: 2012-08 Impact factor: 2.365