BACKGROUND: Overweight and the metabolic syndrome (MS) represent dramatically increasing problems in children and adolescents. Waist circumference (WC) is an important factor to determine MS. So far, WC is a predictor of blood pressure, high-density lipoprotein (HDL), insulin concentration, and visceral fat in adolescents. We investigated whether WC and body mass index standard deviation score (BMI-SDS) are predictors of adiponectin, stromal-derived factor (SDF-1), and soluble E-selectin (sE-selectin) as parameters for beginning insulin resistance and endothelial damage. METHODS: Seventy-nine male Caucasian adolescents were studied, aged 13-17 yr. Thirty-eight (48%) of them had a WC above 90th age percentile. All participants were enrolled in one consultation, recording various parameters and collecting one blood sample. RESULTS: Differences in systolic blood pressure, HDL, high sensitive C-reactive protein, and hemoglobin A1c could be found between groups above or below the 90th WC percentile. Linear regression analysis revealed that WC and BMI-SDS predict traditional risk factors, as well as reduced adiponectin, lower SDF-1, and higher sE-selectin levels. Multiple linear regression analyses show that SDF-1 is in closest correlation to WC and BMI-SDS. CONCLUSIONS: WC and BMI-SDS predict various alterations of traditional and new cardiovascular risk factors. SDF-1 might be a new marker for diagnosis of obesity-related diseases and help understand pathophysiologic mechanisms.
BACKGROUND: Overweight and the metabolic syndrome (MS) represent dramatically increasing problems in children and adolescents. Waist circumference (WC) is an important factor to determine MS. So far, WC is a predictor of blood pressure, high-density lipoprotein (HDL), insulin concentration, and visceral fat in adolescents. We investigated whether WC and body mass index standard deviation score (BMI-SDS) are predictors of adiponectin, stromal-derived factor (SDF-1), and soluble E-selectin (sE-selectin) as parameters for beginning insulin resistance and endothelial damage. METHODS: Seventy-nine male Caucasian adolescents were studied, aged 13-17 yr. Thirty-eight (48%) of them had a WC above 90th age percentile. All participants were enrolled in one consultation, recording various parameters and collecting one blood sample. RESULTS: Differences in systolic blood pressure, HDL, high sensitive C-reactive protein, and hemoglobin A1c could be found between groups above or below the 90th WC percentile. Linear regression analysis revealed that WC and BMI-SDS predict traditional risk factors, as well as reduced adiponectin, lower SDF-1, and higher sE-selectin levels. Multiple linear regression analyses show that SDF-1 is in closest correlation to WC and BMI-SDS. CONCLUSIONS: WC and BMI-SDS predict various alterations of traditional and new cardiovascular risk factors. SDF-1 might be a new marker for diagnosis of obesity-related diseases and help understand pathophysiologic mechanisms.
Authors: Laura D Carbone; Petra Bůžková; Howard A Fink; John A Robbins; Monique Bethel; Mark W Hamrick; William D Hill Journal: Calcif Tissue Int Date: 2017-02-28 Impact factor: 4.333
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Authors: Michael Lichtenauer; Marcus Franz; Michael Fritzenwanger; Hans-Reiner Figulla; Norbert Gerdes; Christian Jung Journal: Biomed Res Int Date: 2015-02-02 Impact factor: 3.411
Authors: Ana Paula Grotti Clemente; Bárbara Dal Molin Netto; Joana Pereira de Carvalho-Ferreira; Raquel Munhoz da Silveira Campos; Aline de Piano Ganen; Lian Tock; Marco Túlio de Mello; Ana Raimunda Dâmaso Journal: Rev Paul Pediatr Date: 2015-12-31