Concentrations of polychlorinated biphenyls in blood of Yusho patients over 35 years after the incident.

We conducted a congener-specific analysis of polychlorinated biphenyls (PCBs) in blood collected from 242 Yusho patients (mean: 65.5 years, median: 67.0 years) and 74 Yusho-suspected persons (mean: 54.7 years, median: 55.0 years) in 2004, and compared each congener concentrations of PCBs among the groups of Yusho patients, Yusho-suspected persons, and normal controls (mean: 68.1 years, median: 67.0 years) with the concentrations previously reported. Among the 209 PCB congeners, 8 congeners of mono-ortho PCBs and 56 congeners of non-dioxin-like PCBs were identified in the blood of Yusho patients and Yusho-suspected persons. Among the PCB congeners measured in the present study, hexaCB-153, hexaCB-138, heptaCB-180, and heptaCB-182/heptaCB-187 showed high ratios to total concentrations of 64 PCB congeners detected in the blood of Yusho patients and Yusho-suspected persons, and the congener profiles were the same as those obtained in normal controls. The sums of the concentrations of 64 PCB congeners in the blood of Yusho patients and Yusho-suspected persons were 40-3032 (mean: 645, median: 536) and 20-1418 (mean: 355, median: 317) ng g(-1) lipid, respectively, and the concentrations were 50% higher and 20% lower than those of normal controls, respectively. The relative contribution ratios of the concentrations of the triCBs, tetraCBs, and pentaCBs to the total concentrations of 64 PCB congeners in the blood of Yusho patients were slightly lower than those of Yusho-suspected persons and normal controls, and the ratios of nonaCBs and decaCB-209 concentrations were nearly the same among the Yusho patients, Yusho-suspected persons, and normal controls. However, the ratios of the concentrations of hexaCBs, heptaCBs, and octaCBs to the total concentrations of 64 PCB congeners in the blood of Yusho patients tended to be slightly higher compared to those of the Yusho-suspected persons and normal controls. From the results comparing the concentrations of 64 PCB congeners in the blood between Yusho patients and normal controls, the concentrations of hexaCB-156, hexaCB-157, heptaCB-181, and heptaCB-189 of the Yusho patients were 3.4, 3.8, 3.9, and 3.8 times higher than those of the normal controls, respectively, indicating that even now, 35 years after exposure, Yusho patients still have a higher concentration of hexaCB-156, hexaCB-157, heptaCB-181, and heptaCB-189 in their blood than do unaffected people. These four congeners may be considered the most important congeners for evaluating the PCBs toxicity of Yusho patients.