Literature DB >> 25629923

Metabolism and metabolites of polychlorinated biphenyls.

Fabian A Grimm1, Dingfei Hu, Izabela Kania-Korwel, Hans-Joachim Lehmler, Gabriele Ludewig, Keri C Hornbuckle, Michael W Duffel, Åke Bergman, Larry W Robertson.   

Abstract

Abstract The metabolism of polychlorinated biphenyls (PCBs) is complex and has an impact on toxicity, and thereby on the assessment of PCB risks. A large number of reactive and stable metabolites are formed in the processes of biotransformation in biota in general, and in humans in particular. The aim of this document is to provide an overview of PCB metabolism, and to identify the metabolites of concern and their occurrence. Emphasis is given to mammalian metabolism of PCBs and their hydroxyl, methylsulfonyl, and sulfated metabolites, especially those that persist in human blood. Potential intracellular targets and health risks are also discussed.

Entities:  

Keywords:  PCB methyl sulfones; PCB sulfates; human exposure; hydroxylated PCBs; polychlorobiphenylols; reactive intermediates

Mesh：

Substances：

Year:  2015        PMID： 25629923      PMCID： PMC4383295          DOI： 10.3109/10408444.2014.999365

Source DB:  PubMed          Journal:  Crit Rev Toxicol        ISSN： 1040-8444            Impact factor:   5.635


  246 in total

1.  Extraction and cleanup methods for analysis of phenolic and neutral organohalogens in plasma.

Authors:  L Hovander; M Athanasiadou; L Asplund; S Jensen; E K Wehler
Journal:  J Anal Toxicol       Date:  2000 Nov-Dec       Impact factor: 3.367

2.  Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters.

Authors:  Monique H A Kester; Sema Bulduk; Hans van Toor; Dick Tibboel; Walter Meinl; Hansruedi Glatt; Charles N Falany; Michael W H Coughtrie; A Gerlienke Schuur; Abraham Brouwer; Theo J Visser
Journal:  J Clin Endocrinol Metab       Date:  2002-03       Impact factor: 5.958

3.  Physicochemical properties of hydroxylated polychlorinated biphenyls aid in predicting their interactions with rat sulfotransferase 1A1 (rSULT1A1).

Authors:  Yungang Liu; Hans-Joachim Lehmler; Larry W Robertson; Michael W Duffel
Journal:  Chem Biol Interact       Date:  2010-12-03       Impact factor: 5.192

4.  Persistent organochlorine pollutants in children working at a waste-disposal site and in young females with high fish consumption in Managua, Nicaragua.

Authors:  Steven N Cuadra; Linda Linderholm; Maria Athanasiadou; Kristina Jakobsson
Journal:  Ambio       Date:  2006-05       Impact factor: 5.129

5.  Subchronic inhalation exposure study of an airborne polychlorinated biphenyl mixture resembling the Chicago ambient air congener profile.

Authors:  Xin Hu; Andrea Adamcakova-Dodd; Hans-Joachim Lehmler; Dingfei Hu; Keri Hornbuckle; Peter S Thorne
Journal:  Environ Sci Technol       Date:  2012-08-24       Impact factor: 9.028

6.  Distribution and excretion of 2,3,6,2',3',6'- and 2,4,5,2',4',5'-hexachlorobiphenyl in senescent rats.

Authors:  L S Birnbaum
Journal:  Toxicol Appl Pharmacol       Date:  1983-09-15       Impact factor: 4.219

7.  Tissue distribution and half-lives of individual polychlorinated biphenyls and serum levels of 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl in the rat.

Authors:  Mattias Oberg; Andreas Sjödin; Helena Casabona; Ingrid Nordgren; Eva Klasson-Wehler; Helen Håkansson
Journal:  Toxicol Sci       Date:  2002-12       Impact factor: 4.849

Review 8.  Catfish consumption as a contributor to elevated PCB levels in a non-Hispanic black subpopulation.

Authors:  Max Weintraub; Linda S Birnbaum
Journal:  Environ Res       Date:  2008-04-14       Impact factor: 6.498

9.  Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthase.

Authors:  Orarat Wangpradit; Lynn M Teesch; S V Santhana Mariappan; Michael W Duffel; Karin Norstrom; Larry W Robertson; Gregor Luthe
Journal:  Chem Res Toxicol       Date:  2009-01       Impact factor: 3.739

10.  The fate of inhaled (14)C-labeled PCB11 and its metabolites in vivo.

Authors:  Xin Hu; Andrea Adamcakova-Dodd; Peter S Thorne
Journal:  Environ Int       Date:  2013-11-22       Impact factor: 9.621
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  103 in total

Review 1.  Polychlorinated biphenyls and links to cardiovascular disease.

Authors:  Jordan T Perkins; Michael C Petriello; Bradley J Newsome; Bernhard Hennig
Journal:  Environ Sci Pollut Res Int       Date:  2015-04-17       Impact factor: 4.223

2.  Accumulation properties of polychlorinated biphenyl congeners in Yusho patients and prediction of their cytochrome P450-dependent metabolism by in silico analysis.

Authors:  Shusaku Hirakawa; Takashi Miyawaki; Tsuguhide Hori; Jumboku Kajiwara; Susumu Katsuki; Masashi Hirano; Yuka Yoshinouchi; Hisato Iwata; Chikage Mitoma; Masutaka Furue
Journal:  Environ Sci Pollut Res Int       Date:  2017-06-21       Impact factor: 4.223

3.  Serum polychlorinated biphenyls and their hydroxylated metabolites are associated with demographic and behavioral factors in children and mothers.

Authors:  Wen Xin Koh; Keri C Hornbuckle; Kai Wang; Peter S Thorne
Journal:  Environ Int       Date:  2016-09       Impact factor: 9.621

4.  Human Liver Microsomes Atropselectively Metabolize 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) to a 1,2-Shift Product as the Major Metabolite.

Authors:  Eric Uwimana; Xueshu Li; Hans-Joachim Lehmler
Journal:  Environ Sci Technol       Date:  2018-04-27       Impact factor: 9.028

5.  Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1.

Authors:  Victoria S Parker; Edwin J Squirewell; Hans-Joachim Lehmler; Larry W Robertson; Michael W Duffel
Journal:  Environ Toxicol Pharmacol       Date:  2018-02-03       Impact factor: 4.860

6.  Polychlorinated biphenyls and their hydroxylated metabolites in the serum of e-waste dismantling workers from eastern China.

Authors:  Shengtao Ma; Guofa Ren; Xiangying Zeng; Zhiqiang Yu; Guoying Sheng; Jiamo Fu
Journal:  Environ Geochem Health       Date:  2017-05-05       Impact factor: 4.609

7.  Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity.

Authors:  Izabela Kania-Korwel; Tracy Lukasiewicz; Christopher D Barnhart; Marianna Stamou; Haeun Chung; Kevin M Kelly; Stelvio Bandiera; Pamela J Lein; Hans-Joachim Lehmler
Journal:  Toxicol Sci       Date:  2017-07-01       Impact factor: 4.849

8.  Uptake, translocation, and metabolism of hydroxylated and methoxylated polychlorinated biphenyls in maize, wheat, and rice.

Authors:  Jianteng Sun; Lili Pan; Jie Chen; Kelun Li; Lizhong Zhu
Journal:  Environ Sci Pollut Res Int       Date:  2016-10-03       Impact factor: 4.223

9.  Evaluation of tetrabromobisphenol A effects on human glucocorticoid and androgen receptors: A comparison of results from human- with yeast-based in vitro assays.

Authors:  Katharina R Beck; Tanja J Sommer; Daniela Schuster; Alex Odermatt
Journal:  Toxicology       Date:  2016-09-28       Impact factor: 4.221

10.  Effects of thiol antioxidants on the atropselective oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) by rat liver microsomes.

Authors:  Xianai Wu; Hans-Joachim Lehmler
Journal:  Environ Sci Pollut Res Int       Date:  2015-07-09       Impact factor: 4.223
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