Literature DB >> 33445793

Aryl Hydrocarbon Receptor and Dioxin-Related Health Hazards-Lessons from Yusho.

Masutaka Furue1,2, Yuji Ishii3, Kiyomi Tsukimori4, Gaku Tsuji1,2.   

Abstract

Poisoning by high concentrations of dioxin and its related compounds manifests variable toxic symptoms such as general malaise, chloracne, hyperpigmentation, sputum and cough, paresthesia or numbness of the extremities, hypertriglyceridemia, perinatal abnormalities, and elevated risks of cancer-related mortality. Such health hazards are observed in patients with Yusho (oil disease in Japanese) who had consumed rice bran oil highly contaminated with 2,3,4,7,8-pentachlorodibenzofuran, polychlorinated biphenyls, and polychlorinated quaterphenyls in 1968. The blood concentrations of these congeners in patients with Yusho remain extremely elevated 50 years after onset. Dioxins exert their toxicity via aryl hydrocarbon receptor (AHR) through the generation of reactive oxygen species (ROS). In this review article, we discuss the pathogenic implication of AHR in dioxin-induced health hazards. We also mention the potential therapeutic use of herbal drugs targeting AHR and ROS in patients with Yusho.

Entities:  

Keywords:  2,3,4,7,8-pentachlorodibenzofuran; Yusho; aryl hydrocarbon receptor; chloracne; dioxin; nuclear factor-erythroid 2-related factor-2; polychlorinated biphenyl; reactive oxygen species; treatment

Mesh：

Substances：

Year:  2021        PMID： 33445793      PMCID： PMC7828254          DOI： 10.3390/ijms22020708

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  230 in total

Review 1.  How it's made: organisational effects of hormones on the developing brain.

Authors:  M M McCarthy
Journal:  J Neuroendocrinol       Date:  2010-07       Impact factor: 3.627

2.  Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes.

Authors:  Haruna Nagayoshi; Norie Murayama; Kensaku Kakimoto; Masaki Tsujino; Shigeo Takenaka; Jun Katahira; Young-Ran Lim; Donghak Kim; Hiroshi Yamazaki; Masayuki Komori; F Peter Guengerich; Tsutomu Shimada
Journal:  Chem Res Toxicol       Date:  2019-04-17       Impact factor: 3.739

3.  Accumulation properties of polychlorinated biphenyl congeners in Yusho patients and prediction of their cytochrome P450-dependent metabolism by in silico analysis.

Authors:  Shusaku Hirakawa; Takashi Miyawaki; Tsuguhide Hori; Jumboku Kajiwara; Susumu Katsuki; Masashi Hirano; Yuka Yoshinouchi; Hisato Iwata; Chikage Mitoma; Masutaka Furue
Journal:  Environ Sci Pollut Res Int       Date:  2017-06-21       Impact factor: 4.223

4.  A technique for identifying three diagnostic findings using association analysis.

Authors:  Tomoaki Imamura; Shinya Matsumoto; Yoshiyuki Kanagawa; Bunichi Tajima; Shiro Matsuya; Masutaka Furue; Hiroshi Oyama
Journal:  Med Biol Eng Comput       Date:  2006-12-15       Impact factor: 2.602

5.  Stimulation of the faecal excretion of 2,4,5,2',4',5'-hexachlorobiphenyl in rats by squalane.

Authors:  E Richter; S G Schäfer; B Fichtl
Journal:  Xenobiotica       Date:  1983-06       Impact factor: 1.908

6.  Arylhydrocarbon receptor (AhR) activation in airway epithelial cells induces MUC5AC via reactive oxygen species (ROS) production.

Authors:  Takahito Chiba; Hiroshi Uchi; Gaku Tsuji; Hisaki Gondo; Yoichi Moroi; Masutaka Furue
Journal:  Pulm Pharmacol Ther       Date:  2010-08-13       Impact factor: 3.410

Review 7.  Yusho and its latest findings-A review in studies conducted by the Yusho Group.

Authors:  Chikage Mitoma; Hiroshi Uchi; Kiyomi Tsukimori; Hideyuki Yamada; Manabu Akahane; Tomoaki Imamura; Atsushi Utani; Masutaka Furue
Journal:  Environ Int       Date:  2015-05-23       Impact factor: 9.621

8.  Polychlorinated biphenyls and dibenzofurans increased abnormal sperm morphology without alterations in aneuploidy: The Yucheng study.

Authors:  Ping-Chi Hsu; Ming-Chieh Li; Yeu-Chin Lee; Pao-Lin Kuo; Yueliang Leon Guo
Journal:  Chemosphere       Date:  2016-09-30       Impact factor: 7.086

9.  Disposition and excretion of 2,3,4,7,8-pentachlorodibenzofuran in the rat.

Authors:  D W Brewster; L S Birnbaum
Journal:  Toxicol Appl Pharmacol       Date:  1987-09-15       Impact factor: 4.219

10.  [The Effect of Maternal Exposure to Dioxins on the Level of Thyroid Hormone in Developing Pups].

Authors:  Yukiko Hattori; Tomoki Takeda; Junki Taura; Hiroaki Kuroki; Yuji Ishii; Hideyuki Yamada
Journal:  Fukuoka Igaku Zasshi       Date:  2015-05
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  1 in total

1.  Effect of Perinatal Dioxin Exposure Originating from Agent Orange on Gaze Behavior in 3-Year-Old Children Living in the Most Dioxin-Contaminated Areas in Vietnam.

Authors:  Thao Ngoc Pham; Muneko Nishijo; Tai Pham-The; Nghi Ngoc Tran; Hoa Thi Vu; Anh Hai Tran; Tien Viet Tran; Yoshikazu Nishino; Hisao Nishijo
Journal:  Toxics       Date:  2022-03-22
  1 in total

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