| Literature DB >> 19070422 |
Masahiko Imai1, Hidetomo Kikuchi, Takanori Denda, Kunio Ohyama, Chieko Hirobe, Hiroo Toyoda.
Abstract
The proliferation of a human colon carcinoma cell line, COLO 201, was effectively suppressed through apoptosis in the presence of flavonoids, an ethanol extract from Vitex agnus-castus fruits. The induction of apoptosis was not inhibited by the presence of an anti-oxidant, N-acetyl-L-cysteine, whereas only HO-1 gene expression levels increased among other typical oxidative stress-associated genes examined after Vitex treatment. These results suggest that Vitex treatment activates a pathway associated with HO-1 gene activation, resulting in the induction of apoptosis in COLO 201. Results also implicate a potential clinical chemotherapeutic application of Vitex for the treatment of colon cancer patients.Entities:
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Year: 2008 PMID： 19070422 DOI： 10.1016/j.canlet.2008.10.036
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679