Literature DB >> 19067174

Integrated wireless neural interface based on the Utah electrode array.

S Kim1, R Bhandari, M Klein, S Negi, L Rieth, P Tathireddy, M Toepper, H Oppermann, F Solzbacher.   

Abstract

This report presents results from research towards a fully integrated, wireless neural interface consisting of a 100-channel microelectrode array, a custom-designed signal processing and telemetry IC, an inductive power receiving coil, and SMD capacitors. An integration concept for such a device was developed, and the materials and methods used to implement this concept were investigated. We developed a multi-level hybrid assembly process that used the Utah Electrode Array (UEA) as a circuit board. The signal processing IC was flip-chip bonded to the UEA using Au/Sn reflow soldering, and included amplifiers for up to 100 channels, signal processing units, an RF transmitter, and a power receiving and clock recovery module. An under bump metallization (UBM) using potentially biocompatible materials was developed and optimized, which consisted of a sputter deposited Ti/Pt/Au thin film stack with layer thicknesses of 50/150/150 nm, respectively. After flip-chip bonding, an underfiller was applied between the IC and the UEA to improve mechanical stability and prevent fluid ingress in in vivo conditions. A planar power receiving coil fabricated by patterning electroplated gold films on polyimide substrates was connected to the IC by using a custom metallized ceramic spacer and SnCu reflow soldering. The SnCu soldering was also used to assemble SMD capacitors on the UEA. The mechanical properties and stability of the optimized interconnections between the UEA and the IC and SMD components were measured. Measurements included the tape tests to evaluate UBM adhesion, shear testing between the Au/Sn solder bumps and the substrate, and accelerated lifetime testing of the long-term stability for the underfiller material coated with a a-SiC(x):H by PECVD, which was intended as a device encapsulation layer. The materials and processes used to generate the integrated neural interface device were found to yield a robust and reliable integrated package.

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Year:  2009        PMID: 19067174     DOI: 10.1007/s10544-008-9251-y

Source DB:  PubMed          Journal:  Biomed Microdevices        ISSN: 1387-2176            Impact factor:   2.838


  33 in total

Review 1.  Autonomous head-mounted electrophysiology systems for freely behaving primates.

Authors:  Vikash Gilja; Cindy A Chestek; Paul Nuyujukian; Justin Foster; Krishna V Shenoy
Journal:  Curr Opin Neurobiol       Date:  2010-07-23       Impact factor: 6.627

2.  Long term in vitro stability of fully integrated wireless neural interfaces based on Utah slant electrode array.

Authors:  Asha Sharma; Loren Rieth; Prashant Tathireddy; Reid Harrison; Florian Solzbacher
Journal:  Appl Phys Lett       Date:  2010-02-17       Impact factor: 3.791

Review 3.  Flexible and stretchable micro-electrodes for in vitro and in vivo neural interfaces.

Authors:  Stéphanie P Lacour; Samia Benmerah; Edward Tarte; James FitzGerald; Jordi Serra; Stephen McMahon; James Fawcett; Oliver Graudejus; Zhe Yu; Barclay Morrison
Journal:  Med Biol Eng Comput       Date:  2010-06-10       Impact factor: 2.602

Review 4.  Implantable neurotechnologies: a review of micro- and nanoelectrodes for neural recording.

Authors:  Anoop C Patil; Nitish V Thakor
Journal:  Med Biol Eng Comput       Date:  2016-01-11       Impact factor: 2.602

5.  In Vitro/Ex Vivo Investigation of Modified Utah Electrode Array to Selectively Sense and Pace the Sub-Surface Cardiac His Bundle.

Authors:  Ankur R Shah; Muhammad S Khan; Annie M Hirahara; Matthias Lange; Ravi Ranjan; Derek J Dosdall
Journal:  ACS Biomater Sci Eng       Date:  2020-05-07

6.  Long-term reliability of Al2O3 and Parylene C bilayer encapsulated Utah electrode array based neural interfaces for chronic implantation.

Authors:  Xianzong Xie; Loren Rieth; Layne Williams; Sandeep Negi; Rajmohan Bhandari; Ryan Caldwell; Rohit Sharma; Prashant Tathireddy; Florian Solzbacher
Journal:  J Neural Eng       Date:  2014-03-24       Impact factor: 5.379

Review 7.  Fast-Scan Cyclic Voltammetry: Chemical Sensing in the Brain and Beyond.

Authors:  James G Roberts; Leslie A Sombers
Journal:  Anal Chem       Date:  2017-12-15       Impact factor: 6.986

8.  A Materials Roadmap to Functional Neural Interface Design.

Authors:  Steven M Wellman; James R Eles; Kip A Ludwig; John P Seymour; Nicholas J Michelson; William E McFadden; Alberto L Vazquez; Takashi D Y Kozai
Journal:  Adv Funct Mater       Date:  2017-07-19       Impact factor: 18.808

9.  Chemical neurostimulation using pulse code modulation (PCM) microfluidic chips.

Authors:  Farouk Azizi; Hui Lu; Hillel J Chiel; Carlos H Mastrangelo
Journal:  J Neurosci Methods       Date:  2010-07-27       Impact factor: 2.390

10.  SELF ALIGNED TIP DEINSULATION OF ATOMIC LAYER DEPOSITED AL2O3 AND PARYLENE C COATED UTAH ELECTRODE ARRAY BASED NEURAL INTERFACES.

Authors:  Xianzong Xie; Loren Rieth; Sandeep Negi; Rajmohan Bhandari; Ryan Caldwell; Rohit Sharma; Prashant Tathireddy; Florian Solzbacher
Journal:  J Micromech Microeng       Date:  2014-03-01       Impact factor: 1.881

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