Literature DB >> 19060166

Enhanced secretion of biologically active murine interleukin-12 by Lactococcus lactis.

Antonio Fernandez1, Nikki Horn, Udo Wegmann, Claudio Nicoletti, Michael J Gasson, Arjan Narbad.   

Abstract

The novel signal peptide SLPmod was used for the secretion of murine interleukin-12 (mIL-12) by Lactococcus lactis. A >4-fold increase in secretion was observed when SLPmod was used instead of the Usp45-derived secretion signal. Oral delivery of this cytokine using the autoinducible host L. lactis FI5876 utilizing SLPmod resulted in a significant increase in mIL-12 plasma levels in mice.

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Year:  2008        PMID： 19060166      PMCID： PMC2632150          DOI： 10.1128/AEM.01728-08

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  17 in total

1.  A lactococcal expression system for engineered nisins.

Authors:  H M Dodd; N Horn; Z Hao; M J Gasson
Journal:  Appl Environ Microbiol       Date:  1992-11       Impact factor: 4.792

2.  Nisin-controlled extracellular production of interleukin-2 in Lactococcus lactis strains, without the requirement for a signal peptide sequence.

Authors:  Antonio Fernández; Juan M Rodríguez; Roy J Bongaerts; Michael J Gasson; Nikki Horn
Journal:  Appl Environ Microbiol       Date:  2007-09-28       Impact factor: 4.792

3.  Introduction of peptidase genes from Lactobacillus delbrueckii subsp. lactis into Lactococcus lactis and controlled expression.

Authors:  U Wegmann; J R Klein; I Drumm; O P Kuipers; B Henrich
Journal:  Appl Environ Microbiol       Date:  1999-11       Impact factor: 4.792

4.  Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.

Authors:  J S Huston; D Levinson; M Mudgett-Hunter; M S Tai; J Novotný; M N Margolies; R J Ridge; R E Bruccoleri; E Haber; R Crea
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

5.  Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.

Authors:  L Steidler; W Hans; L Schotte; S Neirynck; F Obermeier; W Falk; W Fiers; E Remaut
Journal:  Science       Date:  2000-08-25       Impact factor: 47.728

6.  Autoregulation of nisin biosynthesis in Lactococcus lactis by signal transduction.

Authors:  O P Kuipers; M M Beerthuyzen; P G de Ruyter; E J Luesink; W M de Vos
Journal:  J Biol Chem       Date:  1995-11-10       Impact factor: 5.157

7.  Controlled expression and structural organization of a Lactococcus lactis bacteriophage lysin encoded by two overlapping genes.

Authors:  C A Shearman; K L Jury; M J Gasson
Journal:  Appl Environ Microbiol       Date:  1994-09       Impact factor: 4.792

8.  Functional analysis of the Lactococcus lactis usp45 secretion signal in the secretion of a homologous proteinase and a heterologous alpha-amylase.

Authors:  M van Asseldonk; W M de Vos; G Simons
Journal:  Mol Gen Genet       Date:  1993-09

9.  Intranasal immunization with recombinant Lactococcus lactis secreting murine interleukin-12 enhances antigen-specific Th1 cytokine production.

Authors:  Luis G Bermúdez-Humarán; Philippe Langella; Naima G Cortes-Perez; Alexandra Gruss; Reyes S Tamez-Guerra; Sergio C Oliveira; Odila Saucedo-Cardenas; Roberto Montes de Oca-Luna; Yves Le Loir
Journal:  Infect Immun       Date:  2003-04       Impact factor: 3.441

10.  Nisin-controlled production of pediocin PA-1 and colicin V in nisin- and non-nisin-producing Lactococcus lactis strains.

Authors:  Nikki Horn; Antonio Fernández; Helen M Dodd; Michael J Gasson; Juan M Rodríguez
Journal:  Appl Environ Microbiol       Date:  2004-08       Impact factor: 4.792
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5.  Expression and delivery of an endolysin to combat Clostridium perfringens.

Authors:  Teresa Gervasi; Nikki Horn; Udo Wegmann; Giacomo Dugo; Arjan Narbad; Melinda J Mayer
Journal:  Appl Microbiol Biotechnol       Date:  2013-08-15       Impact factor: 4.813

6.  Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice.

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7.  Morphological and Functional Characterization of IL-12Rβ2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation.

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Journal:  Front Immunol       Date:  2018-05-29       Impact factor: 7.561

8.  Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status.

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9.  Construction of a Bioluminescent Labelling Plasmid Vector for Bifidobacteria.

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10.  Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice.

Authors:  Fu Namai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
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  10 in total

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