Literature DB >> 1905694

Abnormal copper accumulation in non-cancerous and cancerous liver tissues of LEC rats developing hereditary hepatitis and spontaneous hepatoma.

Y Li1, Y Togashi, S Sato, T Emoto, J H Kang, N Takeichi, H Kobayashi, Y Kojima, Y Une, J Uchino.   

Abstract

We studied the copper concentrations in the non-cancerous and cancerous liver tissues of LEC rats with hereditary hepatitis and spontaneous hepatoma by atomic absorption spectrophotometry. Copper concentration in the non-cancerous livers of 29-month-old male LEC rats was comparable to that in the livers of LEC rats aged 2, 3 and 8 months whose hepatic copper concentrations were more than 40 times those of normal LEA rats. Copper concentration in spontaneously developed hepatocellular carcinomas of the 29-month-old male LEC rats was lower than that in the surrounding non-cancerous liver tissues, but was still more than 39 times that of 8-month-old male LEA rats. These findings suggest that in LEC rats an abnormal copper metabolism may be maintained during the process of hepatic carcinogenesis.

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Year:  1991        PMID： 1905694      PMCID： PMC5918487          DOI： 10.1111/j.1349-7006.1991.tb01876.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  11 in total

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Journal:  Gastroenterology       Date:  1980-06       Impact factor: 22.682

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Journal:  J Clin Invest       Date:  1991-05       Impact factor: 14.808

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Authors:  K Yamamoto; S Kawanishi
Journal:  J Biol Chem       Date:  1989-09-15       Impact factor: 5.157

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Journal:  Arch Biochem Biophys       Date:  1983-08       Impact factor: 4.013

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Journal:  Lab Anim       Date:  1988-04       Impact factor: 2.471

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Authors:  R Masuda; M C Yoshida; M Sasaki; K Dempo; M Mori
Journal:  Jpn J Cancer Res       Date:  1988-07
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  9 in total

1.  Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans Cinnamon rats.

Authors:  J Kato; M Kobune; Y Kohgo; N Sugawara; H Hisai; T Nakamura; S Sakamaki; N Sawada; Y Niitsu
Journal:  J Clin Invest       Date:  1996-08-15       Impact factor: 14.808

2.  Role of p38 Mapk in development of acute hepatic injury in Long-Evans Cinnamon (LEC) rats, an animal model of human Wilson's disease.

Authors:  Shingo Kadowaki; Saori Meguro; Yoshitaka Imaizumi; Hiroshi Sakai; Daiji Endoh; Masanobu Hayashi
Journal:  J Vet Med Sci       Date:  2013-07-23       Impact factor: 1.267

3.  The role of APE/Ref-1 signaling pathway in hepatocellular carcinoma progression.

Authors:  Zhen Yang; Sun Yang; Bobbye J Misner; Feng Liu-Smith; Frank L Meyskens
Journal:  Int J Oncol       Date:  2014-08-08       Impact factor: 5.650

4.  Abnormal hepatic iron accumulation in LEC rats.

Authors:  J Kato; Y Kohgo; N Sugawara; S Katsuki; N Shintani; K Fujikawa; E Miyazaki; M Kobune; N Takeichi; Y Niitsu
Journal:  Jpn J Cancer Res       Date:  1993-03

5.  Differing distribution of hepatocyte growth factor-positive cells in the liver of LEC rats with acute hepatitis, chronic hepatitis and hepatoma.

Authors:  N Nakayama; H Kashiwazaki; N Kobayashi; J Hamada; K Matsumoto; T Nakamura; N Takeichi
Journal:  Jpn J Cancer Res       Date:  1995-01

6.  Long-Evans A and C rat strains susceptible to clastogenic effects of chemicals in the bone marrow cells.

Authors:  Y Ito; K Fujie; S Matsuda; R Takahashi; S Maeda
Journal:  Jpn J Cancer Res       Date:  1994-01

7.  Absence of linkage between the retinoblastoma gene and hts gene in the LEC rat: a model of human Wilson's disease.

Authors:  N Sasaki; Y Hayashizaki; N Kasai
Journal:  Jpn J Cancer Res       Date:  1993-10

8.  Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver.

Authors:  S Wada; T Kato; M Mutai; K Ozaki; S Yamaguchi; D J Kim; H Baba-Toriyama; M Asamoto; N Ito; H Tsuda
Journal:  Jpn J Cancer Res       Date:  1996-03

9.  Elevated level of 8-hydroxydeoxyguanosine in DNA of liver, kidneys, and brain of Long-Evans Cinnamon rats.

Authors:  F Yamamoto; H Kasai; Y Togashi; N Takeichi; T Hori; S Nishimura
Journal:  Jpn J Cancer Res       Date:  1993-05
  9 in total

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