Literature DB >> 8387476

Abnormal hepatic iron accumulation in LEC rats.

J Kato1, Y Kohgo, N Sugawara, S Katsuki, N Shintani, K Fujikawa, E Miyazaki, M Kobune, N Takeichi, Y Niitsu.   

Abstract

The LEC (Long-Evans cinnamon) rat is a mutant strain displaying hereditary hepatitis and spontaneous hepatocellular carcinoma, and shows abnormal hepatic copper accumulation similar to that occurring in Wilson's disease. We evaluated the iron metabolism of LEC rats compared to LEA (Long-Evans agouti) rats. Hepatic iron and ferritin concentrations were remarkably increased depending on age in LEC rats but not in LEA rats. Increased hepatic iron is normally associated with decreased serum transferrin and total iron binding capacity in hepatic iron overload. In LEC rats, however, both serum transferrin and total iron binding capacity increased with increasing hepatic iron. This increase of serum transferrin and hepatic iron may be an additional important factor contributing to liver injury in LEC rats.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8387476      PMCID： PMC5919139          DOI： 10.1111/j.1349-7006.1993.tb02859.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


Long‐Evans cinnamon Long‐Evans agouti hepatocellular carcinoma superoxide dismutase ethylenediaminetetraacetic acid phenylmethylsulfonyl fluoride phosphate‐buffered saline sodium dodecyl sulfate total iron binding capacity
  14 in total

1.  D-penicillamine prevents the development of hepatitis in Long-Evans Cinnamon rats with abnormal copper metabolism.

Authors:  Y Togashi; Y Li; J H Kang; N Takeichi; Y Fujioka; K Nagashima; H Kobayashi
Journal:  Hepatology       Date:  1992-01       Impact factor: 17.425

Review 2.  Copper and the liver.

Authors:  I Sternlieb
Journal:  Gastroenterology       Date:  1980-06       Impact factor: 22.682

Review 3.  Role of metals in oxygen radical reactions.

Authors:  S D Aust; L A Morehouse; C E Thomas
Journal:  J Free Radic Biol Med       Date:  1985

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  Spontaneous cancer and its possible relationship to oxygen metabolism.

Authors:  J R Totter
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

6.  New mutation causing hereditary hepatitis in the laboratory rat.

Authors:  M C Yoshida; R Masuda; M Sasaki; N Takeichi; H Kobayashi; K Dempo; M Mori
Journal:  J Hered       Date:  1987 Nov-Dec       Impact factor: 2.645

7.  Spontaneous hepatitis in Long-Evans rats. A potential animal model for fulminant hepatitis in man.

Authors:  N Takeichi; H Kobayashi; M C Yoshida; M Sasaki; K Dempo; M Mori
Journal:  Acta Pathol Jpn       Date:  1988-11

8.  Human transferrin. Expression and iron modulation of chimeric genes in transgenic mice.

Authors:  G S Adrian; B H Bowman; D C Herbert; F J Weaker; E K Adrian; L K Robinson; C A Walter; C A Eddy; R Riehl; C J Pauerstein
Journal:  J Biol Chem       Date:  1990-08-05       Impact factor: 5.157

9.  Hereditary hepatitis of LEC rats is controlled by a single autosomal recessive gene.

Authors:  R Masuda; M C Yoshida; M Sasaki; K Dempo; M Mori
Journal:  Lab Anim       Date:  1988-04       Impact factor: 2.471

10.  Abnormal copper accumulation in non-cancerous and cancerous liver tissues of LEC rats developing hereditary hepatitis and spontaneous hepatoma.

Authors:  Y Li; Y Togashi; S Sato; T Emoto; J H Kang; N Takeichi; H Kobayashi; Y Kojima; Y Une; J Uchino
Journal:  Jpn J Cancer Res       Date:  1991-05
View more
  8 in total

1.  Wilson disease: At the crossroads between genetics and epigenetics-A review of the evidence.

Authors:  Dorothy A Kieffer; Valentina Medici
Journal:  Liver Res       Date:  2017-08-16

2.  Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans Cinnamon rats.

Authors:  J Kato; M Kobune; Y Kohgo; N Sugawara; H Hisai; T Nakamura; S Sakamaki; N Sawada; Y Niitsu
Journal:  J Clin Invest       Date:  1996-08-15       Impact factor: 14.808

3.  Histochemical demonstration of copper in LEC rat liver.

Authors:  Y Fujii; K Shimizu; M Satoh; M Fujita; Y Fujioka; Y Li; Y Togashi; N Takeichi; K Nagashima
Journal:  Histochemistry       Date:  1993-10

Review 4.  Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance.

Authors:  Yutaka Kohgo; Katsuya Ikuta; Takaaki Ohtake; Yoshihiro Torimoto; Junji Kato
Journal:  World J Gastroenterol       Date:  2007-09-21       Impact factor: 5.742

5.  Changes in free radical-metabolizing enzymes and lipid peroxides in the liver of Long-Evans with cinnamon-like coat color rats.

Authors:  M Ohhira; M Ono; M Ohhira; C Sekiya; M Namiki; Y Fujimoto; M Nagao; M Mori
Journal:  J Gastroenterol       Date:  1995-10       Impact factor: 7.527

6.  Role of copper accumulation in spontaneous renal carcinogenesis in Long-Evans Cinnamon rats.

Authors:  K Kitaura; Y Chone; N Satake; A Akagi; T Ohnishi; Y Suzuki; K Izumi
Journal:  Jpn J Cancer Res       Date:  1999-04

7.  Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats.

Authors:  T Minami; S Kaneda; T Otsuka; Z Jiao; Y Suzuki; T Yamada; K Matsumoto; K Izumi
Journal:  Jpn J Cancer Res       Date:  2001-08

8.  High sensitivity of LEC rats with chronic hepatitis to hepatocarcinogenesis: decreases in unscheduled and replicative DNA synthesis of the hepatocytes.

Authors:  H Sakamoto; N Sawada; Y Kamimura; K Enomoto; M Mori
Journal:  Jpn J Cancer Res       Date:  1993-09
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.