Literature DB >> 19056891

Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.

Robert A J Signer1, Encarnacion Montecino-Rodriguez, Owen N Witte, Kenneth Dorshkind.   

Abstract

Lymphoid progenitors exhibit severe growth defects during aging while myelopoiesis is relatively unperturbed. These effects are due in part to the preferential expression of p16(Ink4a) and Arf in aged lymphoid progenitors. Their increased expression contributes to reduced growth and survival of lymphoid progenitors and makes them refractory to malignant transformation. Down-regulation of p16(Ink4a) and Arf in aged lymphoid progenitors reverted the senescent phenotype and restored susceptibility to transformation. These data provide a molecular explanation for the preferential effects of aging on lymphopoiesis, suggest that inhibiting p16(Ink4a) and Arf expression can rejuvenate B lymphopoiesis, and link aging and cancer resistance.

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Year:  2008        PMID： 19056891      PMCID： PMC2593609          DOI： 10.1101/gad.1715808

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  38 in total

1.  A clonogenic common myeloid progenitor that gives rise to all myeloid lineages.

Authors:  K Akashi; D Traver; T Miyamoto; I L Weissman
Journal:  Nature       Date:  2000-03-09       Impact factor: 49.962

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Authors:  Juli P Miller; David Allman
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3.  Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.

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Journal:  Nature       Date:  2001-09-06       Impact factor: 49.962

Review 4.  The INK4a/ARF network in tumour suppression.

Authors:  C J Sherr
Journal:  Nat Rev Mol Cell Biol       Date:  2001-10       Impact factor: 94.444

5.  Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

Authors:  In-kyung Park; Dalong Qian; Mark Kiel; Michael W Becker; Michael Pihalja; Irving L Weissman; Sean J Morrison; Michael F Clarke
Journal:  Nature       Date:  2003-04-20       Impact factor: 49.962

6.  Decreased E47 in senescent B cell precursors is stage specific and regulated posttranslationally by protein turnover.

Authors:  Elaine Van der Put; Daniela Frasca; Anne M King; Bonnie B Blomberg; Richard L Riley
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Authors:  Zohar Sachs; Norman E Sharpless; Ronald A DePinho; Naomi Rosenberg
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9.  Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency.

Authors:  Darren J Baker; Carmen Perez-Terzic; Fang Jin; Kevin S Pitel; Kevin Pitel; Nicolas J Niederländer; Karthik Jeganathan; Satsuki Yamada; Santiago Reyes; Lois Rowe; H Jay Hiddinga; Norman L Eberhardt; Andre Terzic; Jan M van Deursen
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Review 10.  The BCR-ABL story: bench to bedside and back.

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  60 in total

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Review 3.  When stem cells grow old: phenotypes and mechanisms of stem cell aging.

Authors:  Michael B Schultz; David A Sinclair
Journal:  Development       Date:  2016-01-01       Impact factor: 6.868

4.  Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer.

Authors:  Hanna K Sanoff; Allison M Deal; Janakiraman Krishnamurthy; Chad Torrice; Patrick Dillon; Jessica Sorrentino; Joseph G Ibrahim; Trevor A Jolly; Grant Williams; Lisa A Carey; Amy Drobish; Brittaney-Belle Gordon; Shani Alston; Arti Hurria; Karin Kleinhans; K Lenhard Rudolph; Norman E Sharpless; Hyman B Muss
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Review 6.  The ageing immune system: is it ever too old to become young again?

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Review 7.  Inflammatory immune cells may impair the preBCR checkpoint, reduce new B cell production, and alter the antibody repertoire in old age.

Authors:  Richard L Riley; Kelly Khomtchouk; Bonnie B Blomberg
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8.  A quantitative model for age-dependent expression of the p16INK4a tumor suppressor.

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Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-14       Impact factor: 11.205

9.  Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects.

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10.  Murine B-1 B cell progenitors initiate B-acute lymphoblastic leukemia with features of high-risk disease.

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