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Literature DB >> 11584300

The INK4a/ARF network in tumour suppression.

Abstract

The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either in whole or in part, in most human cancers. A complex signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli to provide a cell-autonomous mode of tumour surveillance.

Entities: Disease Gene Species

Mesh：

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Year: 2001 PMID： 11584300 DOI： 10.1038/35096061

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

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Cited

271 in total

Review 1. Using mice to examine p53 functions in cancer, aging, and longevity.

Authors: Lawrence A Donehower
Journal: Cold Spring Harb Perspect Biol Date: 2009-11-04 Impact factor: 10.005

2. Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts.

Authors: Fukun Guo; Yi Zheng
Journal: Mol Cell Biol Date: 2004-02 Impact factor: 4.272

3. Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants.

Authors: Byron Hann; Allan Balmain
Journal: J Virol Date: 2003-11 Impact factor: 5.103

4. Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation.

Authors: Jayne M Stommel; Geoffrey M Wahl
Journal: EMBO J Date: 2004-03-18 Impact factor: 11.598

5. Impairment of p53 acetylation, stability and function by an oncogenic transcription factor.

Authors: Alessandra Insinga; Silvia Monestiroli; Simona Ronzoni; Roberta Carbone; Mark Pearson; Giancarlo Pruneri; Giuseppe Viale; Ettore Appella; PierGiuseppe Pelicci; Saverio Minucci
Journal: EMBO J Date: 2004-02-19 Impact factor: 11.598

6. Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts.

Authors: Darren J Perkins; Glen N Barber
Journal: Mol Cell Biol Date: 2004-03 Impact factor: 4.272

The INK4a/ARF network in tumour suppression.

Review 1. Using mice to examine p53 functions in cancer, aging, and longevity.

2. Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts.

3. Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants.

4. Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation.

5. Impairment of p53 acetylation, stability and function by an oncogenic transcription factor.

6. Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts.

7. Different telomere damage signaling pathways in human and mouse cells.

8. The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability.

9. Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis.

10. Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130.