| Literature DB >> 19041764 |
Ningning Wang1, Guangrui Yang, Zhanjun Jia, Hui Zhang, Toshinori Aoyagi, Sunhapas Soodvilai, J David Symons, Jurgen B Schnermann, Frank J Gonzalez, Sheldon E Litwin, Tianxin Yang.
Abstract
Thiazolidinediones (TZDs) are PPARgamma activators that exhibit vasculoprotective properties. To determine the vascular function of PPARgamma, we analyzed Tie2Cre/flox and SM22Cre/flox mice. Unexpectedly, both knockout strains exhibited a significant reduction of circadian variations in blood pressure and heart rate in parallel with diminished variations in urinary norepinephrine/epinephrine excretion and impaired rhythmicity of the canonical clock genes, including Bmal1. PPARgamma expression in the aorta exhibited a robust rhythmicity with a more than 20-fold change during the light/dark cycle. Rosiglitazone treatment induced aortic expression of Bmal1 mRNA, and ChIP and promoter assays revealed that Bmal1 is a direct PPARgamma target gene. These studies have uncovered a role for vascular PPARgamma as a peripheral factor participating in regulation of cardiovascular rhythms.Entities:
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Year: 2008 PMID： 19041764 PMCID： PMC5484540 DOI： 10.1016/j.cmet.2008.10.009
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287