Literature DB >> 19036812

DNA genome size affects the stability of the adenovirus virion.

Adam C Smith1, Kathy L Poulin, Robin J Parks.   

Abstract

Replication-defective adenovirus (Ad) vectors can vary considerably in genome length, but whether this affects virion stability has not been investigated. Helper-dependent Ad vectors with a genome size of approximately 30 kb were 100-fold more sensitive to heat inactivation than their parental helper virus (>36 kb), and increasing the genome size of the vector significantly improved heat stability. A similar relationship between genome size and stability existed for Ad with early region 1 deleted. Loss of infectivity was due to release of vertex proteins, followed by disintegration of the capsid. Thus, not only does the viral DNA encode all of the heritable information essential for virus replication, it also plays a critical role in maintaining capsid strength and integrity.

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Year:  2008        PMID： 19036812      PMCID： PMC2643769          DOI： 10.1128/JVI.01644-08

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

1.  Improved system for helper-dependent adenoviral vector production.

Authors:  Donna Palmer; Philip Ng
Journal:  Mol Ther       Date:  2003-11       Impact factor: 11.454

2.  Activation of adenoviral gene expression by protein IX is not required for efficient virus replication.

Authors:  Kathy L Sargent; Robert A Meulenbroek; Robin J Parks
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

3.  Genome size and structure determine efficiency of postinternalization steps and gene transfer of capsid-modified adenovirus vectors in a cell-type-specific manner.

Authors:  Dmitry M Shayakhmetov; Zong-Yi Li; Anuj Gaggar; Helen Gharwan; Vladimir Ternovoi; Volker Sandig; André Lieber
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

4.  Helper-dependent adenoviral vectors containing modified fiber for improved transduction of developing and mature muscle cells.

Authors:  Jonathan L Bramson; Natalie Grinshtein; Robert A Meulenbroek; John Lunde; Dayantha Kottachchi; Ian A Lorimer; Bernard J Jasmin; Robin J Parks
Journal:  Hum Gene Ther       Date:  2004-02       Impact factor: 5.695

5.  Thermostability/infectivity defect caused by deletion of the core protein V gene in human adenovirus type 5 is rescued by thermo-selectable mutations in the core protein X precursor.

Authors:  Hideyo Ugai; Anton V Borovjagin; Long P Le; Minghui Wang; David T Curiel
Journal:  J Mol Biol       Date:  2006-12-06       Impact factor: 5.469

6.  Structural proteins of adenoviruses. X. Isolation and topography of low molecular weight antigens from the virion of adenovirus type 2.

Authors:  E Everitt; B Sundquist; U Pettersson; L Philipson
Journal:  Virology       Date:  1973-03       Impact factor: 3.616

7.  Internal components of adenovirus.

Authors:  W C Russell; W G Laver; P J Sanderson
Journal:  Nature       Date:  1968-09-14       Impact factor: 49.962

8.  The polypeptides of adenovirus. II. Soluble proteins, cores, top components and the structure of the virion.

Authors:  J V Maizel; D O White; M D Scharff
Journal:  Virology       Date:  1968-09       Impact factor: 3.616

9.  Structure and composition of the adenovirus type 2 core.

Authors:  D T Brown; M Westphal; B T Burlingham; U Winterhoff; W Doerfler
Journal:  J Virol       Date:  1975-08       Impact factor: 5.103

10.  Cancer therapy utilizing an adenoviral vector expressing only E1A.

Authors:  Andrew V Hubberstey; Marta Pavliv; Robin J Parks
Journal:  Cancer Gene Ther       Date:  2002-04       Impact factor: 5.987
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  18 in total

1.  Fusion of Large Polypeptides to Human Adenovirus Type 5 Capsid Protein IX Can Compromise Virion Stability and DNA Packaging Capacity.

Authors:  Kathy L Poulin; Emily R McFall; Grace Chan; Natacha B Provost; Carin Christou; Adam C Smith; Robin J Parks
Journal:  J Virol       Date:  2020-08-17       Impact factor: 5.103

2.  Adenovirus virion stability and the viral genome: size matters.

Authors:  Michael A Kennedy; Robin J Parks
Journal:  Mol Ther       Date:  2009-10       Impact factor: 11.454

3.  Host cell detection of noncoding stuffer DNA contained in helper-dependent adenovirus vectors leads to epigenetic repression of transgene expression.

Authors:  P Joel Ross; Michael A Kennedy; Robin J Parks
Journal:  J Virol       Date:  2009-06-10       Impact factor: 5.103

4.  Assembly of helper-dependent adenovirus DNA into chromatin promotes efficient gene expression.

Authors:  P Joel Ross; Michael A Kennedy; Carin Christou; Milagros Risco Quiroz; Kathy L Poulin; Robin J Parks
Journal:  J Virol       Date:  2011-02-09       Impact factor: 5.103

5.  Distribution of DNA-condensing protein complexes in the adenovirus core.

Authors:  Ana J Pérez-Berná; Sanjin Marion; F Javier Chichón; José J Fernández; Dennis C Winkler; José L Carrascosa; Alasdair C Steven; Antonio Šiber; Carmen San Martín
Journal:  Nucleic Acids Res       Date:  2015-03-27       Impact factor: 16.971

6.  E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes.

Authors:  Stephanie L Sarbanes; Vincent A Blomen; Eric Lam; Søren Heissel; Joseph M Luna; Thijn R Brummelkamp; Erik Falck-Pedersen; H-Heinrich Hoffmann; Charles M Rice
Journal:  Proc Natl Acad Sci U S A       Date:  2020-12-21       Impact factor: 11.205

7.  Proteolytic Cleavage of Bovine Adenovirus 3-Encoded pVIII.

Authors:  Amit Gaba; Lisanework Ayalew; Niraj Makadiya; Suresh Tikoo
Journal:  J Virol       Date:  2017-04-28       Impact factor: 5.103

8.  Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks.

Authors:  Hongrong Liu; Lei Jin; Sok Boon S Koh; Ivo Atanasov; Stan Schein; Lily Wu; Z Hong Zhou
Journal:  Science       Date:  2010-08-27       Impact factor: 47.728

9.  Retargeting of adenovirus vectors through genetic fusion of a single-chain or single-domain antibody to capsid protein IX.

Authors:  Kathy L Poulin; Robert M Lanthier; Adam C Smith; Carin Christou; Milagros Risco Quiroz; Karen L Powell; Ryan W O'Meara; Rashmi Kothary; Ian A Lorimer; Robin J Parks
Journal:  J Virol       Date:  2010-07-14       Impact factor: 5.103

10.  Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.

Authors:  Vincent Fong; Marika Osterbur; Cristina Capella; Yo-El Kim; Christopher Hine; Vera Gorbunova; Andrei Seluanov; Stephen Dewhurst
Journal:  PLoS One       Date:  2011-12-09       Impact factor: 3.240
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