Literature DB >> 19030571

Unprecedented biological cyclopropanation in the biosynthesis of FR-900848.

Tetsuo Tokiwano1, Hiroaki Watanabe, Takashi Seo, Hideaki Oikawa.   

Abstract

We were able to show the predominant incorporation of a single enantiomer and intact incorporation of multiply labelled synthetic diketide precursors (and), which established the intermediacy of cyclopropanated diketide and led to our proposal for the unprecedented biological cyclopropation, via PKS (polyketide synthase) having a novel cyclopropanase domain, in the biosynthesis of FR-900848 (1).

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Year:  2008        PMID： 19030571     DOI： 10.1039/b809610d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

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Authors:  Christopher J Thibodeaux; Wei-chen Chang; Hung-wen Liu
Journal:  Chem Rev       Date:  2011-10-21       Impact factor: 60.622

Review 2.  Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes.

Authors:  Wenqing Chen; Jianzhao Qi; Pan Wu; Dan Wan; Jin Liu; Xuan Feng; Zixin Deng
Journal:  J Ind Microbiol Biotechnol       Date:  2015-07-08       Impact factor: 3.346

3.  Biochemistry: The ylide has landed.

Authors:  Bradley J Landgraf; Squire J Booker
Journal:  Nature       Date:  2013-05-15       Impact factor: 49.962

Review 4.  Identification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics.

Authors:  M McErlean; X Liu; Z Cui; B Gust; S G Van Lanen
Journal:  Nat Prod Rep       Date:  2021-07-21       Impact factor: 15.111

5.  δ-Deuterium isotope effects as probes for transition-state structures of isoprenoid substrates.

Authors:  Seoung-ryoung Choi; Martin Breugst; Kendall N Houk; C Dale Poulter
Journal:  J Org Chem       Date:  2014-04-01       Impact factor: 4.354
  5 in total

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