Literature DB >> 19027993

Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.

Frederico L Gouveia1, Renata M B de Oliveira, Tatiane B de Oliveira, Ivanildo M da Silva, Silene C do Nascimento, Kêsia X F R de Sena, Julianna F C de Albuquerque.   

Abstract

Several 5-arylidene-4-thioxo-thiazolidine-2-ones (3a-n) were synthesized and evaluated as antimicrobial agents against representative strains, including multidrug-resistant strains of clinical isolates. Also, the antiproliferative activity was evaluated against two human carcinoma cell lines (NCI-H292 and HEp-2). The compounds containing the 5-arylidene subunit presented greater antimicrobial activities against Gram positive bacteria, including the multidrug-resistant clinical isolates, than the 4-thioxo-thiazolidine-2-one. Important SAR information was also gathered, such as the contribution of thiocarbonyl attached at 4-position on the thiazolidine heterocyclic for antimicrobial properties. None of the derivatives exhibited significant antiproliferative activity against the human carcinoma cell lines.

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Year:  2008        PMID： 19027993     DOI： 10.1016/j.ejmech.2008.10.006

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  6 in total

1.  5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

Authors:  Venkata Ramana Sirivolu; Sanjeev Kumar V Vernekar; Christophe Marchand; Alena Naumova; Adel Chergui; Amelie Renaud; Andrew G Stephen; Feng Chen; Yuk Y Sham; Yves Pommier; Zhengqiang Wang
Journal:  J Med Chem       Date:  2012-10-08       Impact factor: 7.446

2.  Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation.

Authors:  Amit Gupta; Rajendra Singh; Pankaj K Sonar; Shailendra K Saraf
Journal:  Biochem Res Int       Date:  2016-01-26

3.  Synthesis and biological evaluation of novel imidazolidine derivatives as candidates to schistosomicidal agents.

Authors:  Thiago José Matos-Rocha; Maria do Carmo Alves de Lima; Anekécia Lauro da Silva; Jamerson Ferreira de Oliveira; Allana Lemos Andrade Gouveia; Vinícius Barros Ribeiro da Silva; Antônio Sérgio Alves de Almeida; Fábio André Brayner; Pablo Ramon Gualberto Cardoso; Marina da Rocha Pitta-Galdino; Ivan da Rocha Pitta; Moacyr Jesus Barreto de Melo Rêgo; Luiz Carlos Alves; Maira Galdino da Rocha Pitta
Journal:  Rev Inst Med Trop Sao Paulo       Date:  2017-04-03       Impact factor: 1.846

Review 4.  5-Ene-4-thiazolidinones - An efficient tool in medicinal chemistry.

Authors:  Danylo Kaminskyy; Anna Kryshchyshyn; Roman Lesyk
Journal:  Eur J Med Chem       Date:  2017-09-20       Impact factor: 6.514

Review 5.  Interaction of thiourea and urea with maleimide: comparative theoretical DFT study.

Authors:  Nabila Achoui; Karima Zaioua; Dalila Hammoutène; Bellara Kolli-Nedjar; Yamina Akacem
Journal:  Heliyon       Date:  2019-09-17

6.  Synthesis and antimicrobial activities of 5-Arylidene-thiazolidine-2,4-dione derivatives.

Authors:  Ivanildo Mangueira da Silva; João da Silva Filho; Priscila Brandão Gomes da Silva Santiago; Micalyne Soares do Egito; Carlos André de Souza; Frederico Leite Gouveia; Rafael Matos Ximenes; Kêsia Xisto da Fonseca Ribeiro de Sena; Antonio Rodolfo de Faria; Dalci José Brondani; Julianna Ferreira Cavalcanti de Albuquerque
Journal:  Biomed Res Int       Date:  2014-05-07       Impact factor: 3.411
  6 in total

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