Literature DB >> 3948968

Differential effect of silybin on the Fe2+-ADP and t-butyl hydroperoxide-induced microsomal lipid peroxidation.

A Valenzuela, R Guerra.   

Abstract

We have observed a differential effect of silybin dihemisuccinate on rat liver microsomal oxygen consumption and on lipid peroxidation induced by NADPH-Fe2+-ADP and t-butyl hydroperoxide. These results are ascribed to the antioxidant properties of the flavonoid. The differences observed in the effect of the catalysts may be a consequence of the different capacity of silybin to act as a scavenger of free radicals formed by NADPH-Fe2+-ADP or t-butyl hydroperoxide.

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Year:  1986        PMID： 3948968     DOI： 10.1007/bf01952435

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  ADP-ACTIVATED LIPID PEROXIDATION COUPLED TO THE TPNH OXIDASE SYSTEM OF MICROSOMES.

Authors:  P HOCHSTEIN; L ERNSTER
Journal:  Biochem Biophys Res Commun       Date:  1963-08-14       Impact factor: 3.575

2.  Spin-trapping studies of hydroxyl radical production involved in lipid peroxidation.

Authors:  C S Lai; L H Piette
Journal:  Arch Biochem Biophys       Date:  1978-09       Impact factor: 4.013

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Ultraweak chemiluminescence: a sensitive assay for oxidative radical reactions.

Authors:  A Boveris; E Cadenas; B Chance
Journal:  Fed Proc       Date:  1981-02

5.  Singlet oxygen production associated with hydroperoxide induced lipid peroxidation in liver microsomes.

Authors:  C Auclair; M C Lecomte
Journal:  Biochem Biophys Res Commun       Date:  1978-12-14       Impact factor: 3.575

6.  Inhibitory action of silymarin of lipid peroxide formation in rat liver mitochondria and microsomes.

Authors:  A Bindoli; L Cavallini; N Siliprandi
Journal:  Biochem Pharmacol       Date:  1977-12-15       Impact factor: 5.858

7.  [Silymarin--an inhibitor of horseradish peroxidase (author's transl)].

Authors:  A Greimel; H Koch
Journal:  Experientia       Date:  1977-11-15

8.  Assessment of the scavenging action of reduced glutathione, (+)-cyanidanol-3 and ethanol by the chemiluminescent response of the xanthine oxidase reaction.

Authors:  L A Videla
Journal:  Experientia       Date:  1983-05-15
  8 in total
  4 in total

1.  Comparative bioavailability of Silipide, a new flavanolignan complex, in rats.

Authors:  P Morazzoni; M J Magistretti; C Giachetti; G Zanolo
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1992 Jan-Mar       Impact factor: 2.441

Review 2.  Therapeutic mechanisms and beneficial effects of non-antidiabetic drugs in chronic liver diseases.

Authors:  Han Ah Lee; Young Chang; Pil Soo Sung; Eileen L Yoon; Hye Won Lee; Jeong-Ju Yoo; Young-Sun Lee; Jihyun An; Do Seon Song; Young Youn Cho; Seung Up Kim; Yoon Jun Kim
Journal:  Clin Mol Hepatol       Date:  2022-07-01

3.  Protection against microcystin-LR-induced hepatotoxicity by Silymarin: biochemistry, histopathology, and lethality.

Authors:  K A Mereish; D L Bunner; D R Ragland; D A Creasia
Journal:  Pharm Res       Date:  1991-02       Impact factor: 4.200

4.  Testicular toxicity and sperm quality following cadmium exposure in rats: Ameliorative potentials of Allium cepa.

Authors:  Serah F Ige; Samuel B Olaleye; Roland E Akhigbe; Titilayo A Akanbi; Olanrewaju A Oyekunle; Utibe-Abasi S Udoh
Journal:  J Hum Reprod Sci       Date:  2012-01
  4 in total

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