Literature DB >> 6407109

Atypical pulmonary thrombosis caused by a toxic cyanobacterial peptide.

D N Slatkin, R D Stoner, W H Adams, J H Kycia, H W Siegelman.   

Abstract

Parenteral injection into mice of a toxic pentapeptide isolated from the cyanobacterium Microcystis aeruginosa induced thrombocytopenia, pulmonary thrombi, and hepatic congestion. The lethality of the toxin was unaffected by several anticoagulants. The acute liver damage that follows injection of the toxin has been attributed to direct action on liver cells but may be due to hypoxemia, heart failure, and shock.

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Year:  1983        PMID： 6407109     DOI： 10.1126/science.6407109

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

1.  Pneumonia associated with contact with cyanobacteria.

Authors:  P C Turner; A J Gammie; K Hollinrake; G A Codd
Journal:  BMJ       Date:  1990-06-02

2.  Isolation, culture, and toxicity of the cyanobacterium (blue-green alga) Microcystis aeruginosa from a freshwater source in India.

Authors:  P V Rao; R Bhattacharya; S D Gupta
Journal:  Bull Environ Contam Toxicol       Date:  1994-06       Impact factor: 2.151

3.  Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity.

Authors:  S Yoshizawa; R Matsushima; M F Watanabe; K Harada; A Ichihara; W W Carmichael; H Fujiki
Journal:  J Cancer Res Clin Oncol       Date:  1990       Impact factor: 4.553

4.  Protection against microcystin-LR-induced hepatotoxicity by Silymarin: biochemistry, histopathology, and lethality.

Authors:  K A Mereish; D L Bunner; D R Ragland; D A Creasia
Journal:  Pharm Res       Date:  1991-02       Impact factor: 4.200

5.  Effect of antihepatotoxic agents against microcystin-LR toxicity in cultured rat hepatocytes.

Authors:  K A Mereish; R Solow
Journal:  Pharm Res       Date:  1990-03       Impact factor: 4.200

6.  Inhibition of platelet-aggregating activity in thrombotic thrombocytopenic purpura plasma by normal adult immunoglobulin G.

Authors:  E C Lian; P T Mui; F A Siddiqui; A Y Chiu; L L Chiu
Journal:  J Clin Invest       Date:  1984-02       Impact factor: 14.808

7.  Novel platelet-agglutinating protein from a thrombotic thrombocytopenic purpura plasma.

Authors:  F A Siddiqui; E C Lian
Journal:  J Clin Invest       Date:  1985-10       Impact factor: 14.808

8.  Effect of temperature and light on the toxicity and growth of the blue-green alga Microcystis aeruginosa (UV-006).

Authors:  A J van der Westhuizen; J N Eloff
Journal:  Planta       Date:  1985-01       Impact factor: 4.116

9.  An acute case of intoxication with cyanobacteria and cyanotoxins in recreational water in Salto Grande Dam, Argentina.

Authors:  Leda Giannuzzi; Daniela Sedan; Ricardo Echenique; Dario Andrinolo
Journal:  Mar Drugs       Date:  2011-10-31       Impact factor: 6.085

Review 10.  Microcystin-LR Induced Immunotoxicity in Mammals.

Authors:  Yaqoob Lone; Mangla Bhide; Raj Kumar Koiri
Journal:  J Toxicol       Date:  2016-01-26
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