OBJECTIVES: This study investigates the possibility of a relationship between oversedation and mortality in mechanically ventilated patients. The presence of burst suppression, a pattern of severely decreased brain wave activity on the electroencephalogram, may be unintentionally induced by heavy doses of sedatives. Burst suppression has never been studied as a potential risk factor for death in patients without a known neurologic disorder or injury. DESIGN: Post hoc analysis of a prospectively observational cohort study. SETTING: Medical intensive care units of a tertiary care, university-based medical center. PATIENTS: A total of 125 mechanically ventilated, adult, critically ill patients. MEASUREMENTS AND MAIN RESULTS: A validated arousal scale (Richmond Agitation-Sedation Scale) was used to measure sedation level, and the bispectral index monitor was used to capture electroencephalogram data. Burst suppression occurred in 49 of 125 patients (39%). For analysis, the patients were divided into those with burst suppression (49 of 125, 39%) and those without burst suppression (76 of 125, 61%). All baseline variables were similar between the two groups, with the overall cohort demonstrating a high severity of illness (Acute Physiology and Chronic Health Evaluation II scores of 27.4 +/- 8.2) and 98% receiving sedation. Of those with burst suppression, 29 of 49 (59%) died within 6 months compared with 25 of 76 (33%) who did not demonstrate burst suppression. Using time-dependent Cox regression to adjust for clinically important covariates (age, Charlson comorbidity score, baseline dementia, Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment, coma, and delirium), patients who experienced burst suppression were found to have a statistically significant higher 6-month mortality [Hazard's ratio = 2.04, 95% confidence interval, 1.12-3.70, p = 0.02]. CONCLUSION: The presence of burst suppression, which was unexpectedly high in this medical intensive care unit population, was an independent predictor of increased risk of death at 6 months. This association should be studied prospectively on a larger scale in mechanically ventilated, critically ill patients.
OBJECTIVES: This study investigates the possibility of a relationship between oversedation and mortality in mechanically ventilated patients. The presence of burst suppression, a pattern of severely decreased brain wave activity on the electroencephalogram, may be unintentionally induced by heavy doses of sedatives. Burst suppression has never been studied as a potential risk factor for death in patients without a known neurologic disorder or injury. DESIGN:Post hoc analysis of a prospectively observational cohort study. SETTING: Medical intensive care units of a tertiary care, university-based medical center. PATIENTS: A total of 125 mechanically ventilated, adult, critically illpatients. MEASUREMENTS AND MAIN RESULTS: A validated arousal scale (Richmond Agitation-Sedation Scale) was used to measure sedation level, and the bispectral index monitor was used to capture electroencephalogram data. Burst suppression occurred in 49 of 125 patients (39%). For analysis, the patients were divided into those with burst suppression (49 of 125, 39%) and those without burst suppression (76 of 125, 61%). All baseline variables were similar between the two groups, with the overall cohort demonstrating a high severity of illness (Acute Physiology and Chronic Health Evaluation II scores of 27.4 +/- 8.2) and 98% receiving sedation. Of those with burst suppression, 29 of 49 (59%) died within 6 months compared with 25 of 76 (33%) who did not demonstrate burst suppression. Using time-dependent Cox regression to adjust for clinically important covariates (age, Charlson comorbidity score, baseline dementia, Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment, coma, and delirium), patients who experienced burst suppression were found to have a statistically significant higher 6-month mortality [Hazard's ratio = 2.04, 95% confidence interval, 1.12-3.70, p = 0.02]. CONCLUSION: The presence of burst suppression, which was unexpectedly high in this medical intensive care unit population, was an independent predictor of increased risk of death at 6 months. This association should be studied prospectively on a larger scale in mechanically ventilated, critically illpatients.
Authors: Judith Jacobi; Gilles L Fraser; Douglas B Coursin; Richard R Riker; Dorrie Fontaine; Eric T Wittbrodt; Donald B Chalfin; Michael F Masica; H Scott Bjerke; William M Coplin; David W Crippen; Barry D Fuchs; Ruth M Kelleher; Paul E Marik; Stanley A Nasraway; Michael J Murray; William T Peruzzi; Philip D Lumb Journal: Crit Care Med Date: 2002-01 Impact factor: 7.598
Authors: E W Ely; R Margolin; J Francis; L May; B Truman; R Dittus; T Speroff; S Gautam; G R Bernard; S K Inouye Journal: Crit Care Med Date: 2001-07 Impact factor: 7.598
Authors: J L Vincent; R Moreno; J Takala; S Willatts; A De Mendonça; H Bruining; C K Reinhart; P M Suter; L G Thijs Journal: Intensive Care Med Date: 1996-07 Impact factor: 17.440
Authors: E W Ely; S K Inouye; G R Bernard; S Gordon; J Francis; L May; B Truman; T Speroff; S Gautam; R Margolin; R P Hart; R Dittus Journal: JAMA Date: 2001-12-05 Impact factor: 56.272
Authors: M Willingham; A Ben Abdallah; S Gradwohl; D Helsten; N Lin; A Villafranca; E Jacobsohn; M Avidan; H Kaiser Journal: Br J Anaesth Date: 2014-05-22 Impact factor: 9.166
Authors: David B Seder; Gilles L Fraser; Tracy Robbins; Laurel Libby; Richard R Riker Journal: Intensive Care Med Date: 2009-10-22 Impact factor: 17.440
Authors: Emily J Gilmore; Nicolas Gaspard; Huimahn A Choi; Emily Cohen; Kristin M Burkart; David H Chong; Jan Claassen; Lawrence J Hirsch Journal: Intensive Care Med Date: 2015-03-13 Impact factor: 17.440
Authors: Morgan Le Guen; Ngai Liu; Eric Bourgeois; Thierry Chazot; Daniel I Sessler; Jean-Jacques Rouby; Marc Fischler Journal: Intensive Care Med Date: 2012-12-06 Impact factor: 17.440