Literature DB >> 19018449

Reduced serotonergic functioning changes heart rate in ADHD.

Florian Daniel Zepf1, M Holtmann, C Stadler, L Wöckel, F Poustka.   

Abstract

Reduced mean heart rate (HR) was shown to be a biophysiological marker for aggression, which in turn was proven to be related to changed serotonergic neurotransmission. A total of 16 ADHD-diagnosed boys were subjected to rapid tryptophan depletion (RTD) and a placebo in a double-blind within-subject crossover-design. Mean HR was assessed under RTD/placebo. Low impulsive patients behaving aggressively under RTD showed a lowered HR under RTD versus placebo. Diminished 5-HT functioning was associated with lowered HR and aggressive behaviour.

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Year:  2008        PMID： 19018449     DOI： 10.1007/s00702-008-0146-0

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  18 in total

Review 1.  Individual differences in cardiovascular response to social challenge.

Authors:  Andrea Sgoifo; Tania Costoli; Peter Meerlo; Bauke Buwalda; Maria Angeles Pico'-Alfonso; Sietse De Boer; Ezio Musso; Jaap Koolhaas
Journal:  Neurosci Biobehav Rev       Date:  2004-12-01       Impact factor: 8.989

2.  Similar autonomic responsivity in boys with conduct disorder and their fathers.

Authors:  Sabine C Herpertz; Timo Vloet; Bodo Mueller; Gregor Domes; Klaus Willmes; Beate Herpertz-Dahlmann
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  2007-04       Impact factor: 8.829

3.  Reactive aggression in boys with disruptive behavior disorders: behavior, physiology, and affect.

Authors:  Daniel A Waschbusch; William E Pelham; J Richard Jennings; Andrew R Greiner; Ralph E Tarter; Howard B Moss
Journal:  J Abnorm Child Psychol       Date:  2002-12

4.  Decrease in plasma tryptophan after tryptophan-free amino acid mixtures in man.

Authors:  E A Moja; D M Stoff; G L Gessa; D Castoldi; R Assereto; O Tofanetti
Journal:  Life Sci       Date:  1988       Impact factor: 5.037

5.  Impulsiveness and venturesomeness: their position in a dimensional system of personality description.

Authors:  S B Eysenck; H J Eysenck
Journal:  Psychol Rep       Date:  1978-12

6.  Psychophysiological responses in ADHD boys with and without conduct disorder: implications for adult antisocial behavior.

Authors:  S C Herpertz; B Wenning; B Mueller; M Qunaibi; H Sass; B Herpertz-Dahlmann
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  2001-10       Impact factor: 8.829

7.  Psychophysiology of aggression, psychopathy, and conduct problems: a meta-analysis.

Authors:  Michael F Lorber
Journal:  Psychol Bull       Date:  2004-07       Impact factor: 17.737

8.  Gender differences in the association between cardiovascular reactivity and aggressive conduct.

Authors:  Dianna Murray-Close; Nicki R Crick
Journal:  Int J Psychophysiol       Date:  2007-04-01       Impact factor: 2.997

9.  Serotonergic functioning and trait-impulsivity in attention-deficit/hyperactivity-disordered boys (ADHD): influence of rapid tryptophan depletion.

Authors:  Florian Daniel Zepf; Christina Stadler; Lothar Demisch; Marcus Schmitt; Meike Landgraf; Fritz Poustka
Journal:  Hum Psychopharmacol       Date:  2008-01       Impact factor: 1.672

10.  Diminished serotonergic functioning in hostile children with ADHD: tryptophan depletion increases behavioural inhibition.

Authors:  F D Zepf; M Holtmann; C Stadler; L Demisch; M Schmitt; L Wöckel; F Poustka
Journal:  Pharmacopsychiatry       Date:  2008-03       Impact factor: 5.788
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  9 in total

1.  Acute tryptophan depletion in accordance with body weight: influx of amino acids across the blood-brain barrier.

Authors:  V L S Dingerkus; T J Gaber; K Helmbold; S Bubenzer; A Eisert; C L Sánchez; F D Zepf
Journal:  J Neural Transm (Vienna)       Date:  2012-05-24       Impact factor: 3.575

2.  Change in electrodermal activity after acute tryptophan depletion associated with aggression in young people with attention deficit hyperactivity disorder (ADHD).

Authors:  G G von Polier; C S Biskup; W F Kötting; S Bubenzer; K Helmbold; A Eisert; T J Gaber; F D Zepf
Journal:  J Neural Transm (Vienna)       Date:  2013-12-01       Impact factor: 3.575

3.  Dietary manipulation of serotonergic and dopaminergic function in C57BL/6J mice with amino acid depletion mixtures.

Authors:  Cristina L Sánchez; Amanda E D Van Swearingen; Andrew E Arrant; Cynthia M Kuhn; Florian D Zepf
Journal:  J Neural Transm (Vienna)       Date:  2013-09-24       Impact factor: 3.575

4.  The effects of acute tryptophan depletion on reactive aggression in adults with attention-deficit/hyperactivity disorder (ADHD) and healthy controls.

Authors:  Marco Zimmermann; Marco Grabemann; Christian Mette; Mona Abdel-Hamid; Jennifer Uekermann; Jennifer Ueckermann; Markus Kraemer; Jens Wiltfang; Bernhard Kis; Florian Daniel Zepf
Journal:  PLoS One       Date:  2012-03-14       Impact factor: 3.240

5.  Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice.

Authors:  Caroline Sarah Biskup; Cristina L Sánchez; Andrew Arrant; Amanda E D Van Swearingen; Cynthia Kuhn; Florian Daniel Zepf
Journal:  PLoS One       Date:  2012-05-21       Impact factor: 3.240

6.  Toward a theory of childhood learning disorders, hyperactivity, and aggression.

Authors:  Anthony R Mawson
Journal:  ISRN Psychiatry       Date:  2012-09-27

Review 7.  Attention deficit-hyperactivity disorder and early-onset bipolar disorder: two facets of one entity?

Authors:  Florian D Zepf
Journal:  Dialogues Clin Neurosci       Date:  2009       Impact factor: 5.986

8.  Effects of Dietary Acute Tryptophan Depletion (ATD) on NPY Serum Levels in Healthy Adult Humans Whilst Controlling for Methionine Supply-A Pilot Study.

Authors:  Janice W Y Wong; Hugo A E Morandini; Vita L S Dingerkus; Tilman J Gaber; Kevin C Runions; Pradeep Rao; Simone Mahfouda; Katrin Helmbold; Sarah Bubenzer-Busch; Rebecca Koenemann; Richard M Stewart; Florian D Zepf
Journal:  Nutrients       Date:  2018-05-11       Impact factor: 5.717

9.  Acute Tryptophan Depletion Moja-De: A Method to Study Central Nervous Serotonin Function in Children and Adolescents.

Authors:  Richard M Stewart; Janice W Y Wong; Simone Mahfouda; Hugo A E Morandini; Pradeep Rao; Kevin C Runions; Florian D Zepf
Journal:  Front Psychiatry       Date:  2020-03-06       Impact factor: 4.157
  9 in total

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