Literature DB >> 19006150

Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders.

Patrick T Gunning1, Matthew P Glenn, Khandaker A Z Siddiquee, William P Katt, Eric Masson, Saïd M Sebti, James Turkson, Andrew D Hamilton.   

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Year:  2008        PMID： 19006150      PMCID： PMC2728599          DOI： 10.1002/cbic.200800291

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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  29 in total

Review 1.  Inhibition of protein-protein association by small molecules: approaches and progress.

Authors:  Peter L Toogood
Journal:  J Med Chem       Date:  2002-04-11       Impact factor: 7.446

Review 2.  Stat proteins and oncogenesis.

Authors:  Jacqueline Bromberg
Journal:  J Clin Invest       Date:  2002-05       Impact factor: 14.808

3.  Identification of a high-affinity phosphopeptide inhibitor of Stat3.

Authors:  Zhiyong Ren; Larry A Cabell; Timothy S Schaefer; John S McMurray
Journal:  Bioorg Med Chem Lett       Date:  2003-02-24       Impact factor: 2.823

4.  A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity.

Authors:  D L Boger; B E Fink; S R Brunette; W C Tse; M P Hedrick
Journal:  J Am Chem Soc       Date:  2001-06-27       Impact factor: 15.419

5.  Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway.

Authors:  Lin-Hung Wei; Min-Liang Kuo; Chi-An Chen; Chia-Hung Chou; Kuo-Bau Lai; Chien-Nan Lee; Chang-Yao Hsieh
Journal:  Oncogene       Date:  2003-03-13       Impact factor: 9.867

Review 6.  STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription.

Authors:  R Catlett-Falcone; W S Dalton; R Jove
Journal:  Curr Opin Oncol       Date:  1999-11       Impact factor: 3.645

7.  Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation.

Authors:  J Turkson; D Ryan; J S Kim; Y Zhang; Z Chen; E Haura; A Laudano; S Sebti; A D Hamilton; R Jove
Journal:  J Biol Chem       Date:  2001-09-28       Impact factor: 5.157

8.  Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells.

Authors:  R Garcia; T L Bowman; G Niu; H Yu; S Minton; C A Muro-Cacho; C E Cox; R Falcone; R Fairclough; S Parsons; A Laudano; A Gazit; A Levitzki; A Kraker; R Jove
Journal:  Oncogene       Date:  2001-05-03       Impact factor: 9.867

Review 9.  Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.

Authors:  Ralf Buettner; Linda B Mora; Richard Jove
Journal:  Clin Cancer Res       Date:  2002-04       Impact factor: 12.531

10.  Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis.

Authors:  Steve Alas; Benjamin Bonavida
Journal:  Clin Cancer Res       Date:  2003-01       Impact factor: 12.531
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  20 in total

1.  Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma.

Authors:  Makoto Adachi; Caixia Cui; Cristina T Dodge; Mihir K Bhayani; Stephen Y Lai
Journal:  Oral Oncol       Date:  2012-07-06       Impact factor: 5.337

2.  Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors.

Authors:  Jianyong Chen; Longchuan Bai; Denzil Bernard; Zaneta Nikolovska-Coleska; Cindy Gomez; Jian Zhang; Han Yi; Shaomeng Wang
Journal:  ACS Med Chem Lett       Date:  2010-05-13       Impact factor: 4.345

3.  Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules.

Authors:  Steven Fletcher; Brent D G Page; Xialoei Zhang; Peibin Yue; Zhi Hua Li; Sumaiya Sharmeen; Jagdeep Singh; Wei Zhao; Aaron D Schimmer; Suzanne Trudel; James Turkson; Patrick T Gunning
Journal:  ChemMedChem       Date:  2011-05-25       Impact factor: 3.466

4.  Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway.

Authors:  Xiaomei Ren; Lei Duan; Qiang He; Zhang Zhang; Yi Zhou; Donghai Wu; Jingxuan Pan; Duanqing Pei; Ke Ding
Journal:  ACS Med Chem Lett       Date:  2010-09-07       Impact factor: 4.345

5.  Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry.

Authors:  Priyamvada Acharya; Cajetan Dogo-Isonagie; Judith M LaLonde; Son N Lam; George J Leslie; Mark K Louder; Leah L Frye; Asim K Debnath; Jeremy R Greenwood; Timothy S Luongo; Loïc Martin; K Shawn Watts; James A Hoxie; John R Mascola; Carole A Bewley; Peter D Kwong
Journal:  ACS Chem Biol       Date:  2011-08-05       Impact factor: 5.100

6.  Role of STAT3 in in vitro transformation triggered by TRK oncogenes.

Authors:  Claudia Miranda; Tiziana Fumagalli; Maria Chiara Anania; Maria Grazia Vizioli; Sonia Pagliardini; Marco A Pierotti; Angela Greco
Journal:  PLoS One       Date:  2010-03-03       Impact factor: 3.240

7.  Identification of novel inhibitors that disrupt STAT3-DNA interaction from a γ-AApeptide OBOC combinatorial library.

Authors:  Peng Teng; Xiaolei Zhang; Haifan Wu; Qiao Qiao; Said M Sebti; Jianfeng Cai
Journal:  Chem Commun (Camb)       Date:  2014-06-25       Impact factor: 6.222

Review 8.  Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein.

Authors:  Steven Fletcher; James Turkson; Patrick T Gunning
Journal:  ChemMedChem       Date:  2008-08       Impact factor: 3.466

9.  Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

Authors:  Steven Fletcher; Jagdeep Singh; Xiaolei Zhang; Peibin Yue; Brent D G Page; Sumaiya Sharmeen; Vijay M Shahani; Wei Zhao; Aaron D Schimmer; James Turkson; Patrick T Gunning
Journal:  Chembiochem       Date:  2009-08-17       Impact factor: 3.164

10.  A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes.

Authors:  Xiaolei Zhang; Peibin Yue; Steven Fletcher; Wei Zhao; Patrick T Gunning; James Turkson
Journal:  Biochem Pharmacol       Date:  2010-01-11       Impact factor: 5.858
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