Literature DB >> 1898975

Posttranscriptional regulation of interferon mRNA levels in peritoneal macrophages.

S Gessani1, P Di Marzio, P Rizza, F Belardelli, C Baglioni.   

Abstract

Low levels of beta interferon (IFN) mRNA are transcribed in freshly explanted murine peritoneal macrophages. Nuclear runoff transcription assays show that this "constitutive" IFN-beta-mRNA transcription does not increase in macrophages treated either with lipopolysaccharide or with IFN-gamma, which induce a marked accumulation of this mRNA and greatly increase IFN secretion. Therefore, these agents promote accumulation of IFN-beta mRNA by posttranscriptional mechanisms. The IFN-alpha 2 gene is also constitutively transcribed by macrophages, but the corresponding mRNA does not accumulate in lipopolysaccharide-treated cells.

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Year:  1991        PMID： 1898975      PMCID： PMC239845     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

1.  Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.

Authors:  M E Greenberg; E B Ziff
Journal:  Nature       Date:  1984 Oct 4-10       Impact factor: 49.962

2.  Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells.

Authors:  R L Friedman; S P Manly; M McMahon; I M Kerr; G R Stark
Journal:  Cell       Date:  1984-10       Impact factor: 41.582

3.  Structure and expression of a cloned cDNA for mouse interferon-beta.

Authors:  Y Higashi; Y Sokawa; Y Watanabe; Y Kawade; S Ohno; C Takaoka; T Taniguchi
Journal:  J Biol Chem       Date:  1983-08-10       Impact factor: 5.157

4.  Two levels of regulation of beta-interferon gene expression in human cells.

Authors:  N B Raj; P M Pitha
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

5.  Cell type specific expression and regulation of murine interferon alpha and beta genes.

Authors:  A Hoss-Homfeld; E C Zwarthoff; R Zawatzky
Journal:  Virology       Date:  1989-12       Impact factor: 3.616

6.  Injection of mice with antibody to interferon renders peritoneal macrophages permissive for vesicular stomatitis virus and encephalomyocarditis virus.

Authors:  F Belardelli; F Vignaux; E Proietti; I Gresser
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

7.  Structure and expression of cloned murine IFN-alpha genes.

Authors:  G D Shaw; W Boll; H Taira; N Mantei; P Lengyel; C Weissmann
Journal:  Nucleic Acids Res       Date:  1983-02-11       Impact factor: 16.971

8.  Cloning and expression of murine immune interferon cDNA.

Authors:  P W Gray; D V Goeddel
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

9.  Characterization of the transcription products of glyceraldehyde 3-phosphate-dehydrogenase gene in HeLa cells.

Authors:  C Dani; M Piechaczyk; Y Audigier; S El Sabouty; G Cathala; L Marty; P Fort; J M Blanchard; P Jeanteur
Journal:  Eur J Biochem       Date:  1984-12-03

10.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162
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  4 in total

1.  Posttranscriptional regulation of beta interferon expression in erythroid Friend cells treated with gamma interferon.

Authors:  G Marziali; G Fiorucci; E M Coccia; Z Percario; J Raber; A Battistini; G B Rossi; E Affabris; G Romeo
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

2.  Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages.

Authors:  Antonello Punturieri; Rebecca S Alviani; Timothy Polak; Phil Copper; Joanne Sonstein; Jeffrey L Curtis
Journal:  J Immunol       Date:  2004-07-15       Impact factor: 5.422

3.  Inhibition by interleukin-4 of constitutive beta interferon synthesis in mouse macrophages.

Authors:  P Nickolaus; R Zawatzky
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103

4.  Differential expression of interferon regulatory factor 1 (IRF-1), IRF-2, and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages.

Authors:  S A Barber; M J Fultz; C A Salkowski; S N Vogel
Journal:  Infect Immun       Date:  1995-02       Impact factor: 3.441
  4 in total

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