Literature DB >> 6090941

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.

M E Greenberg, E B Ziff.   

Abstract

Transcription of the c-fos proto-oncogene is greatly increased within minutes of administering purified growth factors to quiescent 3T3 cells. This stimulation is the most rapid transcriptional response to peptide growth factors yet described, and implies a role for c-fos in cell-cycle control. Transformation by c-fos may result from a temporal deregulation of this control.

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Year:  1984        PMID： 6090941     DOI： 10.1038/311433a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  862 in total

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