Literature DB >> 1898667

The Rex proteins of human T-cell leukemia virus type II differ by serine phosphorylation.

P L Green1, Y M Xie, I S Chen.   

Abstract

The Rex proteins of human T-cell leukemia virus types I and II (HTLV-I and HTLV-II) induce cytoplasmic expression of unspliced gag-pol mRNA and singly spliced env mRNA and are critical for virus replication. Two rex gene products, p27rex and p21rex of HTLV-I and p26rex and p24rex of HTLV-II, have been detected in HTLV-infected cells; however, the structural and biological relationship of the proteins has not been clearly elucidated. Endoproteinase digestion and phosphoamino acid analysis of HTLV-II Rex indicated that p24rex has the same amino acid backbone as p26rex and that the larger apparent molecular size of p26rex is attributable to serine phosphorylation.

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Year:  1991        PMID： 1898667      PMCID： PMC240555     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  10 in total

1.  p27x-III and p21x-III, proteins encoded by the pX sequence of human T-cell leukemia virus type I.

Authors:  T Kiyokawa; M Seiki; S Iwashita; K Imagawa; F Shimizu; M Yoshida
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

2.  Characterization of Rous sarcoma virus src gene products synthesized in vitro.

Authors:  K Beemon; T Hunter
Journal:  J Virol       Date:  1978-11       Impact factor: 5.103

3.  Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

Authors:  D W Cleveland; S G Fischer; M W Kirschner; U K Laemmli
Journal:  J Biol Chem       Date:  1977-02-10       Impact factor: 5.157

4.  Transformation by Rous sarcoma virus: a cellular substrate for transformation-specific protein phosphorylation contains phosphotyrosine.

Authors:  K Radke; T Gilmore; G S Martin
Journal:  Cell       Date:  1980-10       Impact factor: 41.582

5.  HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes.

Authors:  J D Rosenblatt; A J Cann; D J Slamon; I S Smalberg; N P Shah; J Fujii; W Wachsman; I S Chen
Journal:  Science       Date:  1988-05-13       Impact factor: 47.728

6.  The internal methionine codons of human T-cell leukemia virus type II rex gene are not required for p24rex production or virus replication and transformation.

Authors:  P L Green; Y M Xie; I S Chen
Journal:  J Virol       Date:  1990-10       Impact factor: 5.103

7.  Molecular characterization of genome of a novel human T-cell leukaemia virus.

Authors:  I S Chen; J McLaughlin; J C Gasson; S C Clark; D W Golde
Journal:  Nature       Date:  1983 Oct 6-12       Impact factor: 49.962

8.  Identification of p26Xb and p24Xb of human T-cell leukemia virus type II.

Authors:  H Shima; M Takano; K Shimotohno; M Miwa
Journal:  FEBS Lett       Date:  1986-12-15       Impact factor: 4.124

9.  A single species of pX mRNA of human T-cell leukemia virus type I encodes trans-activator p40x and two other phosphoproteins.

Authors:  K Nagashima; M Yoshida; M Seiki
Journal:  J Virol       Date:  1986-11       Impact factor: 5.103

10.  Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism.

Authors:  B R Cullen
Journal:  Cell       Date:  1986-09-26       Impact factor: 41.582
  10 in total
  15 in total

Review 1.  The human T-cell leukemia virus Rex protein.

Authors:  Ihab Younis; Patrick L Green
Journal:  Front Biosci       Date:  2005-01-01

2.  Human T-cell leukemia virus type 2 Rex inhibits pre-mRNA splicing in vitro at an early stage of spliceosome formation.

Authors:  A Bakker; X Li; C T Ruland; D W Stephens; A C Black; J D Rosenblatt
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

3.  Human T-cell leukemia virus (HTLV) type II Rex protein binds specifically to RNA sequences of the HTLV long terminal repeat but poorly to the human immunodeficiency virus type 1 Rev-responsive element.

Authors:  M T Yip; W S Dynan; P L Green; A C Black; S J Arrigo; A Torbati; S Heaphy; C Ruland; J D Rosenblatt; I S Chen
Journal:  J Virol       Date:  1991-05       Impact factor: 5.103

4.  Inhibition of human T-cell leukemia virus type 2 Rex function by truncated forms of Rex encoded in alternatively spliced mRNAs.

Authors:  V Ciminale; L Zotti; D M D'Agostino; L Chieco-Bianchi
Journal:  J Virol       Date:  1997-04       Impact factor: 5.103

5.  Phosphorylation of two serine residues regulates human T-cell leukemia virus type 2 Rex function.

Authors:  M Narayan; K Kusuhara; P L Green
Journal:  J Virol       Date:  2001-09       Impact factor: 5.103

6.  PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo.

Authors:  Li Xie; Brenda Yamamoto; Abdelali Haoudi; O John Semmes; Patrick L Green
Journal:  Blood       Date:  2005-11-01       Impact factor: 22.113

7.  Human T-cell leukemia virus type 2 Rex carboxy terminus is an inhibitory/stability domain that regulates Rex functional activity and viral replication.

Authors:  Li Xie; Matthew Kesic; Brenda Yamamoto; Min Li; Ihab Younis; Michael D Lairmore; Patrick L Green
Journal:  J Virol       Date:  2009-03-11       Impact factor: 5.103

8.  Identification of novel singly spliced pX mRNA transcripts common to all human T-cell leukemia virus type 1-related retroviruses.

Authors:  S Orita; S Sato; Y Aono; N Minoura; T Yamashita; Y Hinuma; H Igarashi
Journal:  Virus Genes       Date:  1993-06       Impact factor: 2.332

9.  Tax and overlapping rex sequences do not confer the distinct transformation tropisms of human T-cell leukemia virus types 1 and 2.

Authors:  Jianxin Ye; Li Xie; Patrick L Green
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103

10.  Phosphorylation regulates human T-cell leukemia virus type 1 Rex function.

Authors:  Matthew Kesic; Rami Doueiri; Michael Ward; O John Semmes; Patrick L Green
Journal:  Retrovirology       Date:  2009-11-17       Impact factor: 4.602
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