Literature DB >> 2834826

HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes.

J D Rosenblatt1, A J Cann, D J Slamon, I S Smalberg, N P Shah, J Fujii, W Wachsman, I S Chen.   

Abstract

The human T-cell leukemia virus (HTLV) types I and II have two nonstructural genes that are encoded in overlapping reading frames. One of these genes, known as tax, has been shown to encode a protein responsible for enhanced transcription (transactivation) from the viral long terminal repeats (LTRs). Genetic evidence indicates that the second nonstructural gene of HTLV-II, here designated rex, acts in trans to modulate tax gene-mediated transactivation in a concentration-dependent fashion. The rex gene may regulate the process of transactivation during the viral life cycle.

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Year:  1988        PMID： 2834826     DOI： 10.1126/science.2834826

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  31 in total

1.  Specific binding of the human T-cell leukemia virus type I Rex protein to a short RNA sequence located within the Rex-response element.

Authors:  H P Bogerd; L S Tiley; B R Cullen
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

Review 2.  The human T-cell leukemia virus Rex protein.

Authors:  Ihab Younis; Patrick L Green
Journal:  Front Biosci       Date:  2005-01-01

3.  Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function.

Authors:  A W Cochrane; A Perkins; C A Rosen
Journal:  J Virol       Date:  1990-02       Impact factor: 5.103

4.  Human T-cell leukemia virus type 2 Rex inhibits pre-mRNA splicing in vitro at an early stage of spliceosome formation.

Authors:  A Bakker; X Li; C T Ruland; D W Stephens; A C Black; J D Rosenblatt
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

5.  Specific binding of polypyrimidine tract binding protein and hnRNP A1 to HIV-1 CRS elements.

Authors:  A C Black; J Luo; S Chun; A Bakker; J K Fraser; J D Rosenblatt
Journal:  Virus Genes       Date:  1996       Impact factor: 2.332

Review 6.  The origin and evolution of human T-cell lymphotropic virus types I and II.

Authors:  Y Suzuki; T Gojobori
Journal:  Virus Genes       Date:  1998       Impact factor: 2.332

7.  Chromatin structure of recombinant Moloney murine leukemia virus proviral DNAs that contain tax-responsive sequences from human T-cell lymphotropic virus type II in the presence and absence of tax.

Authors:  H Kitado; H Fan
Journal:  J Virol       Date:  1989-07       Impact factor: 5.103

Review 8.  Viral Evasion and Manipulation of Host RNA Quality Control Pathways.

Authors:  J Robert Hogg
Journal:  J Virol       Date:  2016-07-27       Impact factor: 5.103

9.  Polypyrimidine tract-binding protein and heterogeneous nuclear ribonucleoprotein A1 bind to human T-cell leukemia virus type 2 RNA regulatory elements.

Authors:  A C Black; J Luo; C Watanabe; S Chun; A Bakker; J K Fraser; J P Morgan; J D Rosenblatt
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

10.  Identification of novel singly spliced pX mRNA transcripts common to all human T-cell leukemia virus type 1-related retroviruses.

Authors:  S Orita; S Sato; Y Aono; N Minoura; T Yamashita; Y Hinuma; H Igarashi
Journal:  Virus Genes       Date:  1993-06       Impact factor: 2.332
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