PURPOSE: The aim of this study was to determine if any correlation exists between tumor cell density and fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET)/CT) for pure or predominant ductal carcinoma in situ (DCIS). MATERIALS AND METHODS: Subjects in this retrospective review comprised 11 patients who underwent FDG-PET/CT for DCIS. Pathological tumor cell density and FDG-PET/CT images were compared. A tumor background count density ratio of >1.5 was defined as the detectable range for DCIS. RESULTS: Pathological density of disease was high in eight patients, intermediate in one, and low in two. In all eight patients with a detectable intraductal component on PET/CT, the density of disease was classified as high. In three patients undetected by PET/CT, the density of disease was classified as intermediate or low. On statistical analysis, the correlation between the density of disease and tumor background count density ratio (TBCDR) on PET/CT was significant (<0.05), whereas the nuclear grade and Van Nuys grade were not significant. In the eight patients detected by PET/CT, the discrepancy between histopathological mapping and FDG-PET/CT mapping was >20 mm in four patients and represented underestimation in four patients who showed low density of disease in the peripheral area. CONCLUSIONS: Tumor cell density of intraductal carcinoma appears strongly correlated to detection by FDG-PET/CT.
PURPOSE: The aim of this study was to determine if any correlation exists between tumor cell density and fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET)/CT) for pure or predominant ductal carcinoma in situ (DCIS). MATERIALS AND METHODS: Subjects in this retrospective review comprised 11 patients who underwent FDG-PET/CT for DCIS. Pathological tumor cell density and FDG-PET/CT images were compared. A tumor background count density ratio of >1.5 was defined as the detectable range for DCIS. RESULTS: Pathological density of disease was high in eight patients, intermediate in one, and low in two. In all eight patients with a detectable intraductal component on PET/CT, the density of disease was classified as high. In three patients undetected by PET/CT, the density of disease was classified as intermediate or low. On statistical analysis, the correlation between the density of disease and tumor background count density ratio (TBCDR) on PET/CT was significant (<0.05), whereas the nuclear grade and Van Nuys grade were not significant. In the eight patients detected by PET/CT, the discrepancy between histopathological mapping and FDG-PET/CT mapping was >20 mm in four patients and represented underestimation in four patients who showed low density of disease in the peripheral area. CONCLUSIONS:Tumor cell density of intraductal carcinoma appears strongly correlated to detection by FDG-PET/CT.
Authors: I de Mascarel; F Bonichon; G MacGrogan; C T de Lara; A Avril; V Picot; M Durand; L Mauriac; M Trojani; J M Coindre Journal: Breast Cancer Res Treat Date: 2000-05 Impact factor: 4.872
Authors: A Y Rostom; J Powe; A Kandil; A Ezzat; S Bakheet; F el-Khwsky; G el-Hussainy; R Sorbris; O Sjoklint Journal: Br J Radiol Date: 1999-11 Impact factor: 3.039
Authors: N Avril; J Dose; F Jänicke; S Bense; S Ziegler; C Laubenbacher; W Römer; H Pache; M Herz; B Allgayer; W Nathrath; H Graeff; M Schwaiger Journal: J Clin Oncol Date: 1996-06 Impact factor: 44.544
Authors: N Avril; C A Rosé; M Schelling; J Dose; W Kuhn; S Bense; W Weber; S Ziegler; H Graeff; M Schwaiger Journal: J Clin Oncol Date: 2000-10-15 Impact factor: 44.544
Authors: F Dehdashti; J E Mortimer; B A Siegel; L K Griffeth; T J Bonasera; M J Fusselman; D D Detert; P D Cutler; J A Katzenellenbogen; M J Welch Journal: J Nucl Med Date: 1995-10 Impact factor: 10.057
Authors: A Schaefer; M Vermandel; C Baillet; A S Dewalle-Vignion; R Modzelewski; P Vera; L Massoptier; C Parcq; D Gibon; T Fechter; U Nemer; I Gardin; U Nestle Journal: Eur J Nucl Med Mol Imaging Date: 2015-11-14 Impact factor: 9.236