Literature DB >> 1897426

Neurofibrillary tangles and histamine-containing neurons in Alzheimer hypothalamus.

M S Airaksinen1, K Reinikainen, P Riekkinen, P Panula.   

Abstract

The location of histamine-immunoreactive (IR) cell bodies in normal aged human brain and in cases of Alzheimer's disease (AD) were compared to the distribution of neurofibrillary tangles (NFT). Cryostat sections were fixed with carbodiimide and processed for histamine-immunohistochemistry using the PAP technique. NFT were visualized in the same sections using thioflavin. Histamine-IR cell bodies in human brain were concentrated in the tuberomammillary (TM) nucleus that embodied a major part of the hypothalamus. Although located in similar large profiles and mainly concentrated in the TM area, the numerous hypothalamic NFT in AD were seldom found within the histamine-IR neurons.

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Year:  1991        PMID： 1897426     DOI： 10.1007/bf01993139

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  5 in total

1.  Changes in the regional brain histamine and histidine levels in postmortem brains of Alzheimer patients.

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5.  Hypothalamic pathology in Alzheimer's disease.

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