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Literature DB >> 2325846

A histamine-containing neuronal system in human brain.

P Panula¹, M S Airaksinen, U Pirvola, E Kotilainen.

Abstract

A well-organized network of varicose fibers was revealed throughout the frontal and temporal cortex of adult humans with specific antisera against histamine. The densest network of fibers was seen in lamina I, where varicose fibers were seen to run in parallel to the overlying pia mater. Electron microscopic immunohistochemistry revealed histamine-immunostaining in granules in a small number of nerve fibers and varicosities. Hypothalamic samples obtained from autopsy brains of adult humans revealed numerous histamine-immunoreactive nerve cell bodies in the posterior basal hypothalamus in and around the tuberomammillary nucleus. The results suggest that a histaminergic neuronal system reminiscent of that described in rodents is present in human brain.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Histamine

Year: 1990 PMID： 2325846 DOI： 10.1016/0306-4522(90)90307-p

Source DB: PubMed Journal: Neuroscience ISSN： 0306-4522 Impact factor: 3.590

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Cited

44 in total

1. Major changes in the brain histamine system of the ground squirrel Citellus lateralis during hibernation.

Authors: T Sallmen; A L Beckman; T L Stanton; K S Eriksson; J Tarhanen; L Tuomisto; P Panula
Journal: J Neurosci Date: 1999-03-01 Impact factor: 6.167

2. The orexin/hypocretin system in zebrafish is connected to the aminergic and cholinergic systems.

Authors: Jan Kaslin; Johanna M Nystedt; Maria Ostergård; Nina Peitsaro; Pertti Panula
Journal: J Neurosci Date: 2004-03-17 Impact factor: 6.167

3. Histamine and tyrosine hydroxylase in developing rat brain.

Authors: A Kinnunen; P Panula
Journal: Agents Actions Date: 1991-05

4. Histaminergic neurons protect the developing hippocampus from kainic acid-induced neuronal damage in an organotypic coculture system.

Authors: Tiina-Kaisa Kukko-Lukjanov; Sanna Soini; Tomi Taira; Kimmo A Michelsen; Pertti Panula; Irma E Holopainen
Journal: J Neurosci Date: 2006-01-25 Impact factor: 6.167

A histamine-containing neuronal system in human brain.

1. Major changes in the brain histamine system of the ground squirrel Citellus lateralis during hibernation.

2. The orexin/hypocretin system in zebrafish is connected to the aminergic and cholinergic systems.

3. Histamine and tyrosine hydroxylase in developing rat brain.

4. Histaminergic neurons protect the developing hippocampus from kainic acid-induced neuronal damage in an organotypic coculture system.

5. Immunocytochemical and biochemical studies of histamine in the retina of the turtle Pseudemys scripta.

6. Selective monoaminergic and histaminergic circuit dysregulation following long-term HIV-1 protein exposure.

Review 7. Pattern of brain destruction in Parkinson's and Alzheimer's diseases.

8. Cerebral Dopamine Neurotrophic Factor Regulates Multiple Neuronal Subtypes and Behavior.

Review 9. Brain histamine modulates recognition memory: possible implications in major cognitive disorders.

10. Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus.