Literature DB >> 2713757

Changes in the regional brain histamine and histidine levels in postmortem brains of Alzheimer patients.

I M Mazurkiewicz-Kwilecki1, S Nsonwah.   

Abstract

In postmortem brains of Alzheimer patients, statistically significant decreases in histamine levels were observed in the frontal (45%), temporal (20%), and occipital cortices (38%) and in the caudate nucleus (25%). Histidine levels were decreased in the frontal (15%), temporal (21%), and occipital cortices (30%) and in the caudate nucleus (25%); the decrease was statistically significant in the last two brain regions. Histamine was determined by the double isotope technique, and histidine was determined fluorometrically by a fluorescamine method. The data indicate that brain histamine regulation is altered in Alzheimer's disease.

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Year:  1989        PMID： 2713757     DOI： 10.1139/y89-013

Source DB:  PubMed          Journal:  Can J Physiol Pharmacol        ISSN： 0008-4212            Impact factor:   2.273


  14 in total

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Journal:  Hum Mol Genet       Date:  2015-07-23       Impact factor: 6.150

Review 4.  Mouse behavioural analysis in systems biology.

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Journal:  Br J Pharmacol       Date:  2009-02-16       Impact factor: 8.739

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Authors:  M S Airaksinen; K Reinikainen; P Riekkinen; P Panula
Journal:  Agents Actions       Date:  1991-05

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Journal:  Mol Neurobiol       Date:  2016-07-01       Impact factor: 5.590

Review 9.  Tacrine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in Alzheimer's disease.

Authors:  A J Wagstaff; D McTavish
Journal:  Drugs Aging       Date:  1994-06       Impact factor: 3.923

10.  Histamine H3 receptor antagonists/inverse agonists on cognitive and motor processes: relevance to Alzheimer's disease, ADHD, schizophrenia, and drug abuse.

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Journal:  Front Syst Neurosci       Date:  2012-10-23
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