| Literature DB >> 18957858 |
Tina Hölscher1, Ute Schleyer, Marcel Merfort, Stephanie Bringer-Meyer, Helmut Görisch, Hermann Sahm.
Abstract
Gluconobacter oxydans is famous for its rapid and incomplete oxidation of a wide range of sugars and sugar alcohols. The organism is known for its efficient oxidation of D-glucose to D-gluconate, which can be further oxidized to two different keto-D-gluconates, 2-keto-D-gluconate and 5-keto-D-gluconate, as well as 2,5-di-keto-D-gluconate. For this oxidation chain and for further oxidation reactions, G. oxydans possesses a high number of membrane-bound dehydrogenases. In this review, we focus on the dehydrogenases involved in D-glucose oxidation and the products formed during this process. As some of the involved dehydrogenases contain pyrroloquinoline quinone (PQQ) as a cofactor, also PQQ synthesis is reviewed. Finally, we will give an overview of further PQQ-dependent dehydrogenases and discuss their functions in G. oxydans ATCC 621H (DSM 2343). Copyright (c) 2008 S. Karger AG, Basel.Entities:
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Year: 2008 PMID： 18957858 DOI： 10.1159/000142890
Source DB: PubMed Journal: J Mol Microbiol Biotechnol ISSN： 1464-1801