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Literature DB >> 18955731

The role of dysfunctional HDL in atherosclerosis.

Mohamad Navab¹, Srinivasa T Reddy, Brian J Van Lenten, G M Anantharamaiah, Alan M Fogelman.

Abstract

This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2008 PMID： 18955731 PMCID： PMC2674720 DOI： 10.1194/jlr.R800036-JLR200

Source DB: PubMed Journal: J Lipid Res ISSN： 0022-2275 Impact factor: 5.922

40 in total

1. ApoA-I mimetic peptides with differing ability to inhibit atherosclerosis also exhibit differences in their interactions with membrane bilayers.

Authors: Shaila P Handattu; David W Garber; Dawn C Horn; Donald W Hughes; Bob Berno; Alex D Bain; Vinod K Mishra; Mayakonda N Palgunachari; Geeta Datta; G M Anantharamaiah; Richard M Epand
Journal: J Biol Chem Date: 2006-11-16 Impact factor: 5.157

2. The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction.

Authors: Zhiping Wu; Matthew A Wagner; Lemin Zheng; John S Parks; Jacinto M Shy; Jonathan D Smith; Valentin Gogonea; Stanley L Hazen
Journal: Nat Struct Mol Biol Date: 2007-08-05 Impact factor: 15.369

3. Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL.

Authors: Tomas Vaisar; Subramaniam Pennathur; Pattie S Green; Sina A Gharib; Andrew N Hoofnagle; Marian C Cheung; Jaeman Byun; Simona Vuletic; Sean Kassim; Pragya Singh; Helen Chea; Robert H Knopp; John Brunzell; Randolph Geary; Alan Chait; Xue-Qiao Zhao; Keith Elkon; Santica Marcovina; Paul Ridker; John F Oram; Jay W Heinecke
Journal: J Clin Invest Date: 2007-03 Impact factor: 14.808

4. Effect of a short-term diet and exercise intervention on inflammatory/anti-inflammatory properties of HDL in overweight/obese men with cardiovascular risk factors.

Authors: Christian K Roberts; Carey Ng; Susan Hama; Anna Jane Eliseo; R James Barnard
Journal: J Appl Physiol (1985) Date: 2006-08-10

5. Inability of HDL from abdominally obese subjects to counteract the inhibitory effect of oxidized LDL on vasorelaxation.

Authors: Laurence Perségol; Bruno Vergès; Philippe Gambert; Laurence Duvillard
Journal: J Lipid Res Date: 2007-02-28 Impact factor: 5.922

6. Proinflammatory high-density lipoprotein as a biomarker for atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritis.

Authors: Maureen McMahon; Jennifer Grossman; John FitzGerald; Erika Dahlin-Lee; Daniel J Wallace; Bernard Y Thong; Humeira Badsha; Kenneth Kalunian; Christina Charles; Mohamad Navab; Alan M Fogelman; Bevra H Hahn
Journal: Arthritis Rheum Date: 2006-08

7. Effects of D-4F on vasodilation, oxidative stress, angiostatin, myocardial inflammation, and angiogenic potential in tight-skin mice.

Authors: Dorothee Weihrauch; Hao Xu; Yang Shi; Jingli Wang; Jennifer Brien; Deron W Jones; Sushma Kaul; Richard A Komorowski; Mary Ellen Csuka; Keith T Oldham; Kirkwood A Pritchard
Journal: Am J Physiol Heart Circ Physiol Date: 2007-05-11 Impact factor: 4.733

8. HDL-inflammatory index correlates with poor outcome in hemodialysis patients.

Authors: K Kalantar-Zadeh; J D Kopple; N Kamranpour; A M Fogelman; M Navab
Journal: Kidney Int Date: 2007-08-29 Impact factor: 10.612

9. Effects of high-dose atorvastatin on antiinflammatory properties of high density lipoprotein in patients with rheumatoid arthritis: a pilot study.

Authors: Christina Charles-Schoeman; Dinesh Khanna; Daniel E Furst; Maureen McMahon; Srinivasa T Reddy; Alan M Fogelman; Harold E Paulus; Grace S Park; Timothy Gong; Benjamin J Ansell
Journal: J Rheumatol Date: 2007-06-01 Impact factor: 4.666

10. Lipoprotein inflammatory properties and serum amyloid A levels but not cholesterol levels predict lesion area in cholesterol-fed rabbits.

Authors: Brian J Van Lenten; Alan C Wagner; Mohamad Navab; G M Anantharamaiah; Susan Hama; Srinivasa T Reddy; Alan M Fogelman
Journal: J Lipid Res Date: 2007-08-10 Impact factor: 5.922

73 in total

The role of dysfunctional HDL in atherosclerosis.

1. ApoA-I mimetic peptides with differing ability to inhibit atherosclerosis also exhibit differences in their interactions with membrane bilayers.

2. The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction.

3. Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL.

4. Effect of a short-term diet and exercise intervention on inflammatory/anti-inflammatory properties of HDL in overweight/obese men with cardiovascular risk factors.

5. Inability of HDL from abdominally obese subjects to counteract the inhibitory effect of oxidized LDL on vasorelaxation.

6. Proinflammatory high-density lipoprotein as a biomarker for atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritis.

7. Effects of D-4F on vasodilation, oxidative stress, angiostatin, myocardial inflammation, and angiogenic potential in tight-skin mice.

8. HDL-inflammatory index correlates with poor outcome in hemodialysis patients.

9. Effects of high-dose atorvastatin on antiinflammatory properties of high density lipoprotein in patients with rheumatoid arthritis: a pilot study.

10. Lipoprotein inflammatory properties and serum amyloid A levels but not cholesterol levels predict lesion area in cholesterol-fed rabbits.

1. Psoriasis: it's more than just the skin.

Review 2. Anti-oxidant properties of high-density lipoprotein and atherosclerosis.

3. Apolipoprotein mimetic peptides: Mechanisms of action as anti-atherogenic agents.

4. A biochemical fluorometric method for assessing the oxidative properties of HDL.

Review 5. Auto-antibodies as emergent prognostic markers and possible mediators of ischemic cardiovascular diseases.

Review 6. Lipid abnormalities in kidney disease and management strategies.

7. Limitations of a Cardiac Risk (QRISK2) Calculator in Patients with High Density Lipoprotein (HDL).

8. Postpartum weight retention is associated with elevated ratio of oxidized LDL lipids to HDL-cholesterol.

Review 9. Synthetic high-density lipoprotein-like nanoparticles for cancer therapy.

Review 10. Role of HDL dysfunction in end-stage renal disease: a double-edged sword.