Literature DB >> 18952590

Convection-enhanced delivery for the treatment of pediatric neurologic disorders.

Debbie K Song1, Russell R Lonser.   

Abstract

Direct perfusion of specific regions of the central nervous system by convection-enhanced delivery is becoming more widely used for the delivery of compounds in the research and treatment of various neural disorders. In contrast to other currently available central nervous system delivery techniques, convection-enhanced delivery relies on bulk flow for distribution of solute. This allows for safe, targeted, reliable, and homogeneous delivery of small-molecular-weight and large-molecular-weight substances over clinically relevant volumes in a manner that bypasses the blood-central nervous system barrier. Recent studies have also shown that coinfused imaging surrogate tracers can be used to monitor and control the convective distribution of therapeutic agents in vivo. The unique features of convection-enhanced delivery, including the ability to monitor distribution in realtime, provide an opportunity to develop new research and treatment paradigms for pediatric patients with a variety of intrinsic central nervous system disorders.

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Year:  2008        PMID： 18952590      PMCID： PMC3674562          DOI： 10.1177/0883073808321064

Source DB:  PubMed          Journal:  J Child Neurol        ISSN： 0883-0738            Impact factor:   1.987


  21 in total

1.  Imaging-guided convection-enhanced delivery and gene therapy of glioblastoma.

Authors:  Juergen Voges; Regina Reszka; Axel Gossmann; Claus Dittmar; Raphaela Richter; Guido Garlip; Lutz Kracht; Heinz H Coenen; Volker Sturm; Karl Wienhard; Wolf-Dieter Heiss; Andreas H Jacobs
Journal:  Ann Neurol       Date:  2003-10       Impact factor: 10.422

2.  Convective distribution of macromolecules in the primate brain demonstrated using computerized tomography and magnetic resonance imaging.

Authors:  Tung T Nguyen; Yashdip S Pannu; Cynthia Sung; Robert L Dedrick; Stuart Walbridge; Martin W Brechbiel; Kayhan Garmestani; Markus Beitzel; Alexander T Yordanov; Edward H Oldfield
Journal:  J Neurosurg       Date:  2003-03       Impact factor: 5.115

3.  Chronic interstitial infusion of protein to primate brain: determination of drug distribution and clearance with single-photon emission computerized tomography imaging.

Authors:  D W Laske; P F Morrison; D M Lieberman; M E Corthesy; J C Reynolds; P A Stewart-Henney; S S Koong; A Cummins; C H Paik; E H Oldfield
Journal:  J Neurosurg       Date:  1997-10       Impact factor: 5.115

4.  Direct convective delivery of macromolecules to peripheral nerves.

Authors:  R R Lonser; R J Weil; P F Morrison; L S Governale; E H Oldfield
Journal:  J Neurosurg       Date:  1998-10       Impact factor: 5.115

Review 5.  Drug delivery to the brain.

Authors:  W M Pardridge
Journal:  J Cereb Blood Flow Metab       Date:  1997-07       Impact factor: 6.200

6.  Convection-enhanced delivery of macromolecules in the brain.

Authors:  R H Bobo; D W Laske; A Akbasak; P F Morrison; R L Dedrick; E H Oldfield
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-15       Impact factor: 11.205

7.  Intracerebral clysis in a rat glioma model.

Authors:  J N Bruce; A Falavigna; J P Johnson; J S Hall; B D Birch; J T Yoon; E X Wu; R L Fine; A T Parsa
Journal:  Neurosurgery       Date:  2000-03       Impact factor: 4.654

8.  Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease.

Authors:  Steven S Gill; Nikunj K Patel; Gary R Hotton; Karen O'Sullivan; Renée McCarter; Martin Bunnage; David J Brooks; Clive N Svendsen; Peter Heywood
Journal:  Nat Med       Date:  2003-03-31       Impact factor: 53.440

9.  Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group.

Authors:  Sandeep Kunwar; Michael D Prados; Susan M Chang; Mitchel S Berger; Frederick F Lang; Joseph M Piepmeier; John H Sampson; Zvi Ram; Philip H Gutin; Robert D Gibbons; Kenneth D Aldape; David J Croteau; Jeffrey W Sherman; Raj K Puri
Journal:  J Clin Oncol       Date:  2007-03-01       Impact factor: 44.544

10.  Safety and efficacy of convection-enhanced delivery of gemcitabine or carboplatin in a malignant glioma model in rats.

Authors:  Jeffrey W Degen; Stuart Walbridge; Alexander O Vortmeyer; Edward H Oldfield; Russell R Lonser
Journal:  J Neurosurg       Date:  2003-11       Impact factor: 5.115
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  14 in total

1.  Dynamic contrast-enhanced MRI of Gd-albumin delivery to the rat hippocampus in vivo by convection-enhanced delivery.

Authors:  Jung Hwan Kim; Garrett W Astary; Tatiana L Nobrega; Svetlana Kantorovich; Paul R Carney; Thomas H Mareci; Malisa Sarntinoranont
Journal:  J Neurosci Methods       Date:  2012-06-08       Impact factor: 2.390

2.  Efficacy of vincristine administered via convection-enhanced delivery in a rodent brainstem tumor model documented by bioluminescence imaging.

Authors:  Guifa Xi; Veena Rajaram; Babara Mania-Farnell; Chandra S Mayanil; Marcelo B Soares; Tadanori Tomita; Stewart Goldman
Journal:  Childs Nerv Syst       Date:  2012-01-27       Impact factor: 1.475

Review 3.  Oligonucleotide therapeutic approaches for Huntington disease.

Authors:  Dinah W Y Sah; Neil Aronin
Journal:  J Clin Invest       Date:  2011-02-01       Impact factor: 14.808

4.  Safety and tolerability of magnetic resonance imaging-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in nonhuman primate striatum.

Authors:  Waldy San Sebastian; R Mark Richardson; Adrian P Kells; Clementine Lamarre; John Bringas; Philip Pivirotto; Ernesto A Salegio; Stephen J Dearmond; John Forsayeth; Krystof S Bankiewicz
Journal:  Hum Gene Ther       Date:  2012-01-26       Impact factor: 5.695

Review 5.  Pediatric diffuse intrinsic pontine glioma: can optimism replace pessimism?

Authors:  Darren Hargrave
Journal:  CNS Oncol       Date:  2012-11

Review 6.  Convection-enhanced delivery for the treatment of brain tumors.

Authors:  Waldemar Debinski; Stephen B Tatter
Journal:  Expert Rev Neurother       Date:  2009-10       Impact factor: 4.618

7.  A Novel Methodology for Applying Multivoxel MR Spectroscopy to Evaluate Convection-Enhanced Drug Delivery in Diffuse Intrinsic Pontine Gliomas.

Authors:  D I Guisado; R Singh; S Minkowitz; Z Zhou; S Haque; K K Peck; R J Young; A J Tsiouris; M M Souweidane; S B Thakur
Journal:  AJNR Am J Neuroradiol       Date:  2016-03-03       Impact factor: 3.825

8.  Regional convection-enhanced delivery of gadolinium-labeled albumin in the rat hippocampus in vivo.

Authors:  Garrett W Astary; Svetlana Kantorovich; Paul R Carney; Thomas H Mareci; Malisa Sarntinoranont
Journal:  J Neurosci Methods       Date:  2010-01-11       Impact factor: 2.390

9.  Image-guided convection-enhanced delivery into agarose gel models of the brain.

Authors:  Karl A Sillay; S Gray McClatchy; Brandon A Shepherd; Garrett T Venable; Tyler S Fuehrer
Journal:  J Vis Exp       Date:  2014-05-14       Impact factor: 1.355

10.  Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans.

Authors:  John H Sampson; Martin Brady; Raghu Raghavan; Ankit I Mehta; Allan H Friedman; David A Reardon; Neil A Petry; Daniel P Barboriak; Terence Z Wong; Michael R Zalutsky; Denise Lally-Goss; Darell D Bigner
Journal:  Neurosurgery       Date:  2011-09       Impact factor: 4.654
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