PURPOSE: To investigate brain metabolite change in rat migraine model by proton magnetic resonance spectroscopy (1H-MRS) in vivo and ex vivo. METHODS: 18 Adult SD rats were enrolled in the study. After nitroglycerin administration, the migraine rat model was established according to ethology evaluation. 1H-MRS was performed at 3T MR scanner in vivo and 14.7T Bruker MR spectrometer ex vivo. Area of peak for different metabolite material was obtained and compared by using independent-T test. The significance level was set at p<0.05. RESULTS: In thalami of experimental group, areas of peak for Cho, Cr and Glu both in vivo and ex vivo were higher than in control group(p<0.05). In contrast, there was no statistical difference in cerebellum. CONCLUSION: The elevated Cho and Cr spectral pattern were found in rat migraine model. Neuron activity in thalamus is significantly changeable during attacks.
PURPOSE: To investigate brain metabolite change in ratmigraine model by proton magnetic resonance spectroscopy (1H-MRS) in vivo and ex vivo. METHODS: 18 Adult SD rats were enrolled in the study. After nitroglycerin administration, the migrainerat model was established according to ethology evaluation. 1H-MRS was performed at 3T MR scanner in vivo and 14.7T Bruker MR spectrometer ex vivo. Area of peak for different metabolite material was obtained and compared by using independent-T test. The significance level was set at p<0.05. RESULTS: In thalami of experimental group, areas of peak for Cho, Cr and Glu both in vivo and ex vivo were higher than in control group(p<0.05). In contrast, there was no statistical difference in cerebellum. CONCLUSION: The elevated Cho and Cr spectral pattern were found in ratmigraine model. Neuron activity in thalamus is significantly changeable during attacks.
Authors: Xianghong Arakaki; Gary Galbraith; Victor Pikov; Alfred N Fonteh; Michael G Harrington Journal: Brain Res Date: 2014-03-27 Impact factor: 3.252
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