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Literature DB >> 18931791

Pseudouridines in rRNA helix 69 play a role in loop stacking interactions.

Jean-Paul Desaulniers¹, Yu-Cheng Chang, Raviprasad Aduri, Sanjaya C Abeysirigunawardena, John SantaLucia, Christine S Chow.

Abstract

The (1)H NMR spectra of RNAs representing E. coli 23S rRNA helix 69 with [1,3-(15)N]pseudouridine modification at specific sites reveal unique roles for pseudouridine in stabilizing base-stacking interactions in the hairpin loop region.

Entities: Chemical Species

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Year: 2008 PMID： 18931791 DOI： 10.1039/b812731j

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

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Cited

19 in total

1. Pseudouridine modifications influence binding of aminoglycosides to helix 69 of bacterial ribosomes.

Authors: Yogo Sakakibara; Christine S Chow
Journal: Org Biomol Chem Date: 2017-10-18 Impact factor: 3.876

2. Probing conformational states of modified helix 69 in 50S ribosomes.

Authors: Yogo Sakakibara; Christine S Chow
Journal: J Am Chem Soc Date: 2011-05-16 Impact factor: 15.419

3. Dynamic stacking of an expected branch point adenosine in duplexes containing pseudouridine-modified or unmodified U2 snRNA sites.

Authors: Scott D Kennedy; William J Bauer; Wenhua Wang; Clara L Kielkopf
Journal: Biochem Biophys Res Commun Date: 2019-02-21 Impact factor: 3.575

Pseudouridines in rRNA helix 69 play a role in loop stacking interactions.

1. Pseudouridine modifications influence binding of aminoglycosides to helix 69 of bacterial ribosomes.

2. Probing conformational states of modified helix 69 in 50S ribosomes.

3. Dynamic stacking of an expected branch point adenosine in duplexes containing pseudouridine-modified or unmodified U2 snRNA sites.

4. An atlas of RNA base pairs involving modified nucleobases with optimal geometries and accurate energies.

5. Modulation of conformational changes in helix 69 mutants by pseudouridine modifications.

Review 6. Pseudouridine: still mysterious, but never a fake (uridine)!

7. Ligand- and pH-induced conformational changes of RNA domain helix 69 revealed by 2-aminopurine fluorescence.

8. Binding of aminoglycoside antibiotics to helix 69 of 23S rRNA.

9. Selection of heptapeptides that bind helix 69 of bacterial 23S ribosomal RNA.

Review 10. Regulation and Function of RNA Pseudouridylation in Human Cells.