| Literature DB >> 18927591 |
Fernán Agüero1, Bissan Al-Lazikani, Martin Aslett, Matthew Berriman, Frederick S Buckner, Robert K Campbell, Santiago Carmona, Ian M Carruthers, A W Edith Chan, Feng Chen, Gregory J Crowther, Maria A Doyle, Christiane Hertz-Fowler, Andrew L Hopkins, Gregg McAllister, Solomon Nwaka, John P Overington, Arnab Pain, Gaia V Paolini, Ursula Pieper, Stuart A Ralph, Aaron Riechers, David S Roos, Andrej Sali, Dhanasekaran Shanmugam, Takashi Suzuki, Wesley C Van Voorhis, Christophe L M J Verlinde.
Abstract
The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.Entities:
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Year: 2008 PMID： 18927591 PMCID： PMC3184002 DOI： 10.1038/nrd2684
Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694