STATEMENT OF PROBLEM: Acrylic resins are prone to microbial adherence, especially by Candida albicans. Surface-charged resins alter the ionic interaction between the denture resin and Candida hyphae, and these resins are being developed as a means to reduce microbial colonization on the denture surface. PURPOSE: The purpose of this study was to investigate the physical and mechanical properties of phosphate-containing polymethyl methacrylate resins for their suitability as a denture material. MATERIAL AND METHODS: Using PMMA with cross-linker (Lucitone 199) as a control, 4 experimental groups containing various levels of phosphate with and without cross-linker were generated. The properties examined were impact strength, fracture toughness, wettability (contact angle), and resin bonding ability to denture teeth. Impact strength was tested in the Izod configuration (n=16), and fracture toughness (n=13) was measured using the single-edge notched bend test. Wettability was determined by calculating the contact angle of water on the material surface (n=12), while ISO 1567 was used for bonding ability (n=12). The data were analyzed by 1- and 2-way ANOVA (alpha=.05). RESULTS: A trend of increased hydrophilicity, as indicated by lower contact angle, was observed with increased concentrations of phosphate. With regard to the other properties, no significant differences were found when compared with the control acrylic resin. CONCLUSIONS: No adverse physical effect due to the addition of a phosphate-containing monomer was found in the acrylic denture resins. Additional mechanical and physical properties, biocompatibility, and clinical efficacy studies are needed to confirm the in vivo anti-Candida activity of these novel resins.
STATEMENT OF PROBLEM: Acrylic resins are prone to microbial adherence, especially by Candida albicans. Surface-charged resins alter the ionic interaction between the denture resin and Candida hyphae, and these resins are being developed as a means to reduce microbial colonization on the denture surface. PURPOSE: The purpose of this study was to investigate the physical and mechanical properties of phosphate-containing polymethyl methacrylate resins for their suitability as a denture material. MATERIAL AND METHODS: Using PMMA with cross-linker (Lucitone 199) as a control, 4 experimental groups containing various levels of phosphate with and without cross-linker were generated. The properties examined were impact strength, fracture toughness, wettability (contact angle), and resin bonding ability to denture teeth. Impact strength was tested in the Izod configuration (n=16), and fracture toughness (n=13) was measured using the single-edge notched bend test. Wettability was determined by calculating the contact angle of water on the material surface (n=12), while ISO 1567 was used for bonding ability (n=12). The data were analyzed by 1- and 2-way ANOVA (alpha=.05). RESULTS: A trend of increased hydrophilicity, as indicated by lower contact angle, was observed with increased concentrations of phosphate. With regard to the other properties, no significant differences were found when compared with the control acrylic resin. CONCLUSIONS: No adverse physical effect due to the addition of a phosphate-containing monomer was found in the acrylic denture resins. Additional mechanical and physical properties, biocompatibility, and clinical efficacy studies are needed to confirm the in vivo anti-Candida activity of these novel resins.
Authors: J Chandra; P K Mukherjee; S D Leidich; F F Faddoul; L L Hoyer; L J Douglas; M A Ghannoum Journal: J Dent Res Date: 2001-03 Impact factor: 6.116
Authors: Gunjan Dhir; David W Berzins; Virendra B Dhuru; A Raj Periathamby; Andrew Dentino Journal: J Prosthodont Date: 2007-08-02 Impact factor: 2.752
Authors: Stefano P Bachmann; Gordon Ramage; Kacy VandeWalle; Thomas F Patterson; Brian L Wickes; José L López-Ribot Journal: Antimicrob Agents Chemother Date: 2003-11 Impact factor: 5.191
Authors: Tomohiro Hoshika; Yoshihiro Nishitani; Masahiro Yoshiyama; William O Key; William Brantley; Kelli A Agee; Lorenzo Breschi; Milena Cadenaro; Franklin R Tay; Frederick Rueggeberg; David H Pashley Journal: Dent Mater Date: 2014-09-04 Impact factor: 5.304
Authors: Cíntia de Souza Silva; Ana Lucia Machado; Carolina de Andrade Lima Chaves; Ana Cláudia Pavarina; Carlos Eduardo Vergani Journal: J Appl Oral Sci Date: 2013 Impact factor: 2.698