Literature DB >> 1889625

Fluorescence approaches to the study of the p21ras GTPase mechanism.

J F Eccleston1, K J Moore, G G Brownbridge, M R Webb, P N Lowe.   

Abstract

The use of ribose-modified guanine nucleotides and tryptophan mutants of p21ras, neither of which have significant effect on the kinetic mechanism of the p21ras GTPase and the GAP-activated p21ras GTPase, will now allow a detailed kinetic study of how GAP and other regulatory proteins interact with p21ras. This will lead to a better understanding of how the relative concentrations of 'active' p21ras. GTP and 'inactive' p21ras. GDP are regulated in the cell.

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Year:  1991        PMID： 1889625     DOI： 10.1042/bst0190432

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  13 in total

1.  Comparative single-molecule and ensemble myosin enzymology: sulfoindocyanine ATP and ADP derivatives.

Authors:  K Oiwa; J F Eccleston; M Anson; M Kikumoto; C T Davis; G P Reid; M A Ferenczi; J E Corrie; A Yamada; H Nakayama; D R Trentham
Journal:  Biophys J       Date:  2000-06       Impact factor: 4.033

2.  Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction?

Authors:  Michael J Seewald; Astrid Kraemer; Marian Farkasovsky; Carolin Körner; Alfred Wittinghofer; Ingrid R Vetter
Journal:  Mol Cell Biol       Date:  2003-11       Impact factor: 4.272

3.  Spontaneous nucleotide exchange in low molecular weight GTPases by fluorescently labeled gamma-phosphate-linked GTP analogs.

Authors:  Jonas Korlach; Daniel W Baird; Ahmed A Heikal; Kyle R Gee; Gregory R Hoffman; Watt W Webb
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-18       Impact factor: 11.205

4.  A systems mechanism for KRAS mutant allele-specific responses to targeted therapy.

Authors:  Thomas McFall; Jolene K Diedrich; Meron Mengistu; Stacy L Littlechild; Kendra V Paskvan; Laura Sisk-Hackworth; James J Moresco; Andrey S Shaw; Edward C Stites
Journal:  Sci Signal       Date:  2019-09-24       Impact factor: 8.192

Review 5.  New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling.

Authors:  Keesha E Erickson; Oleksii S Rukhlenko; Richard G Posner; William S Hlavacek; Boris N Kholodenko
Journal:  Semin Cancer Biol       Date:  2018-03-05       Impact factor: 15.707

6.  Fluorescent coumarin-labeled nucleotides to measure ADP release from actomyosin.

Authors:  M R Webb; J E Corrie
Journal:  Biophys J       Date:  2001-09       Impact factor: 4.033

7.  Tissue-Specific Oncogenic Activity of KRASA146T.

Authors:  Asim K Bera; Jia Lu; Emily J Poulin; Yi-Jang Lin; Samantha Dale Strasser; Joao A Paulo; Tannie Q Huang; Carolina Morales; Wei Yan; Joshua Cook; Jonathan A Nowak; Douglas K Brubaker; Brian A Joughin; Christian W Johnson; Rebecca A DeStefanis; Phaedra C Ghazi; Sudershan Gondi; Thomas E Wales; Roxana E Iacob; Lana Bogdanova; Jessica J Gierut; Yina Li; John R Engen; Pedro A Perez-Mancera; Benjamin S Braun; Steven P Gygi; Douglas A Lauffenburger; Kenneth D Westover; Kevin M Haigis
Journal:  Cancer Discov       Date:  2019-04-05       Impact factor: 39.397

8.  The conformation of the active site of myosin probed using mant-nucleotides.

Authors:  K Franks-Skiba; R Cooke
Journal:  Biophys J       Date:  1995-04       Impact factor: 4.033

9.  KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation.

Authors:  Jia Lu; Asim K Bera; Sudershan Gondi; Kenneth D Westover
Journal:  Biochemistry       Date:  2017-12-28       Impact factor: 3.162

10.  ATPase cycle and DNA unwinding kinetics of RecG helicase.

Authors:  Christopher P Toseland; Ben Powell; Martin R Webb
Journal:  PLoS One       Date:  2012-06-06       Impact factor: 3.240
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