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Literature DB >> 1888644

Dose-related analgesic effects of flupirtine.

T Hummel¹, T Friedmann, E Pauli, G Niebch, H O Borbe, G Kobal.

Abstract

1. Flupirtine is a novel and, in all probability, centrally acting, analgesic. The present investigation was conducted in order to investigate dose-related effects of perorally administered flupirtine in man, with special regard to specifically analgesic actions, employing a model based on pain-related chemosomatosensory evoked potentials and subjective intensity estimates of painful stimuli. 2. Plasma concentrations of flupirtine measured 2 h after dosing linearly increased as a function of the administered dose. 3. It was possible to reproduce our own previously obtained results, which established the analgesic action of 200 mg flupirtine administered perorally. 4. Intensity estimates linearly decreased as a function of the administered dose, whereas chemosomatosensory evoked potential amplitudes non-linearly changed in relation to the administered dose. 5. In the spontaneous EEG, a dose-dependent increment in the power-spectra was observed, and this mainly in the alpha- and beta-range.

Entities: Chemical Disease Species

Mesh：

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Year: 1991 PMID： 1888644 PMCID： PMC1368495 DOI： 10.1111/j.1365-2125.1991.tb05615.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

25 in total

1. Cortical responses to painful CO2 stimulation of nasal mucosa; a magnetoencephalographic study in man.

Authors: J Huttunen; G Kobal; E Kaukoranta; R Hari
Journal: Electroencephalogr Clin Neurophysiol Date: 1986-10

2. Use of flupirtine maleate as an analgesic in patients with liver disease.

Authors: P Powell-Jackson; R Williams
Journal: Br J Clin Pract Date: 1985-02

3. Effects of flupirtine on the pain-related evoked potential and the spontaneous EEG.

Authors: G Kobal; T Hummel
Journal: Agents Actions Date: 1988-02

4. [The effect of flupirtine, various analgesics and muscle relaxants on skeletal muscle tone in the conscious rat].

Authors: B Nickel; V Jakovlev; I Szelenyi
Journal: Arzneimittelforschung Date: 1990-08

5. Clinical experience with flupirtine in the U.S.

Authors: F G McMahon; W F Arndt; J J Newton; P A Montgomery; J L Perhach
Journal: Postgrad Med J Date: 1987 Impact factor: 2.401

6. Pharmaco-electroencephalography in the rat as a method for characterization of different types of analgesics.

Authors: B Nickel; H Zerrahn
Journal: Postgrad Med J Date: 1987 Impact factor: 2.401

7. The analgesic efficacy of flupirtine in comparison to pentazocine and placebo assessed by EEG and subjective pain ratings.

Authors: B Bromm; R Ganzel; W M Herrmann; W Meier; E Scharein
Journal: Postgrad Med J Date: 1987 Impact factor: 2.401

8. Analgesic efficacy and safety of oral flupirtine in the treatment of cancer pain.

Authors: W Scheef
Journal: Postgrad Med J Date: 1987 Impact factor: 2.401

9. Efficacy and tolerance of flupirtine and pentazocine in two multicentre trials.

Authors: J H Heusinger
Journal: Postgrad Med J Date: 1987 Impact factor: 2.401

10. Flupirtine antinociception in the dog is primarily mediated by nonopioid supraspinal mechanisms.

Authors: D B Vaupel; B Nickel; K Becketts
Journal: Eur J Pharmacol Date: 1989-03-29 Impact factor: 4.432

19 in total

1. Expression and function of the K+ channel KCNQ genes in human arteries.

Authors: Fu Liang Ng; Alison J Davis; Thomas A Jepps; Maksym I Harhun; Shuk Yin Yeung; Andrew Wan; Marcus Reddy; David Melville; Antonio Nardi; Teck K Khong; Iain A Greenwood
Journal: Br J Pharmacol Date: 2011-01 Impact factor: 8.739

Review 2. Clinical pharmacology of analgesics assessed with human experimental pain models: bridging basic and clinical research.

Authors: Bruno Georg Oertel; Jörn Lötsch
Journal: Br J Pharmacol Date: 2013-02 Impact factor: 8.739

Dose-related analgesic effects of flupirtine.

1. Cortical responses to painful CO2 stimulation of nasal mucosa; a magnetoencephalographic study in man.

2. Use of flupirtine maleate as an analgesic in patients with liver disease.

3. Effects of flupirtine on the pain-related evoked potential and the spontaneous EEG.

4. [The effect of flupirtine, various analgesics and muscle relaxants on skeletal muscle tone in the conscious rat].

5. Clinical experience with flupirtine in the U.S.

6. Pharmaco-electroencephalography in the rat as a method for characterization of different types of analgesics.

7. The analgesic efficacy of flupirtine in comparison to pentazocine and placebo assessed by EEG and subjective pain ratings.

8. Analgesic efficacy and safety of oral flupirtine in the treatment of cancer pain.

9. Efficacy and tolerance of flupirtine and pentazocine in two multicentre trials.

10. Flupirtine antinociception in the dog is primarily mediated by nonopioid supraspinal mechanisms.

1. Expression and function of the K+ channel KCNQ genes in human arteries.

Review 2. Clinical pharmacology of analgesics assessed with human experimental pain models: bridging basic and clinical research.

3. Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine.

Review 4. Flupirtine in pain management: pharmacological properties and clinical use.

Review 5. Flupirtine, a re-discovered drug, revisited.

Review 6. Flupirtine. A review of its pharmacological properties, and therapeutic efficacy in pain states.

Review 7. Electroencephalography and analgesics.

8. Dose-related effects of ibuprofen on pain-related potentials.

9. Effects of flurbiprofen enantiomers on pain-related chemo-somatosensory evoked potentials in human subjects.

10. A comparison of the antinociceptive effects of imipramine, tramadol and anpirtoline.