Literature DB >> 1888632

Lack of effect of flosequinan on the pharmacokinetics of theophylline.

F Kamali1, C Edwards, M D Rawlins.   

Abstract

The pharmacokinetics of theophylline (240 mg) p.o. were studied before and after the administration of oral flosequinan for 14 days in 21 healthy volunteers using a randomised cross-over design. Comparisons of Cmax, tmax, AUC, CL of theophylline and urinary recovery of the parent drug and metabolites showed that flosequinan had no significant effect on the disposition of theophylline.

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Year:  1991        PMID： 1888632      PMCID： PMC1368504          DOI： 10.1111/j.1365-2125.1991.tb05624.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  9 in total

1.  New synthetic quinolone antibacterial agents and serum concentration of theophylline.

Authors:  Y Niki; R Soejima; H Kawane; M Sumi; S Umeki
Journal:  Chest       Date:  1987-10       Impact factor: 9.410

2.  Effects of time of dosing and age on intravenous aminophylline pharmacokinetics.

Authors:  A Rodgers; K W Woodhouse; D N Bateman
Journal:  Br J Clin Pharmacol       Date:  1987-03       Impact factor: 4.335

3.  The pharmacokinetics and haemodynamics of BTS 49 465 and its major metabolite in healthy volunteers.

Authors:  R D Wynne; E L Crampton; I D Hind
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

4.  Effect of enoxacin and 4-oxo-enoxacin on antipyrine disposition in the rat.

Authors:  D J Edwards; N M Waite; C K Svensson
Journal:  Drug Metab Dispos       Date:  1988 Jul-Aug       Impact factor: 3.922

5.  Impact of ciprofloxacin on theophylline clearance and steady-state concentrations in serum.

Authors:  J Schwartz; L Jauregui; J Lettieri; K Bachmann
Journal:  Antimicrob Agents Chemother       Date:  1988-01       Impact factor: 5.191

6.  Simultaneous determinations by theophylline and its major metabolites in urine by reversed-phase ion-pair high-performance liquid chromatography.

Authors:  K T Muir; J H Jonkman; D S Tang; M Kunitani; S Riegelman
Journal:  J Chromatogr       Date:  1980-11-14

7.  Enoxacin decreases the clearance of theophylline in man.

Authors:  W J Wijnands; T B Vree; C L Van Herwaarden
Journal:  Br J Clin Pharmacol       Date:  1985-12       Impact factor: 4.335

8.  The influence of quinolone derivatives on theophylline clearance.

Authors:  W J Wijnands; T B Vree; C L van Herwaarden
Journal:  Br J Clin Pharmacol       Date:  1986-12       Impact factor: 4.335

9.  Enoxacin--a potent inhibitor of theophylline metabolism.

Authors:  J Beckmann; W Elsässer; U Gundert-Remy; R Hertrampf
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953
  9 in total
  1 in total

Review 1.  Influence of endogenous and exogenous effectors on the pharmacokinetics of theophylline. Focus on biotransformation.

Authors:  U Tröger; F P Meyer
Journal:  Clin Pharmacokinet       Date:  1995-04       Impact factor: 6.447
  1 in total

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