Literature DB >> 7451627

Simultaneous determinations by theophylline and its major metabolites in urine by reversed-phase ion-pair high-performance liquid chromatography.

K T Muir, J H Jonkman, D S Tang, M Kunitani, S Riegelman.   

Abstract

A new, highly slective high-performance liquid-chromatographic (HPLC) assay for theophylline and its major metabolites in urine is described. The method utilizes an ion-pair extraction followed by separation and quantitation by reversed-phase ion-pair gradient-elution HPLC. Comparison with several other methods showed that interferences were present in too many blank urine samples to allow for the accurate quantitation of the metabolites of theophylline by direct injection--isocratic HPLC assays. Sample processing involving ion-pair complexing and extraction together with gradient-elution systems is recommended for accurate pharmacokinetic studies.

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Year:  1980        PMID： 7451627     DOI： 10.1016/s0378-4347(00)81010-5

Source DB:  PubMed          Journal:  J Chromatogr


  21 in total

1.  Lack of effect of short-term passive smoking on the metabolic disposition of theophylline.

Authors:  D T Casto; B M Schnapf; M A Clotz
Journal:  Eur J Clin Pharmacol       Date:  1990       Impact factor: 2.953

2.  Lack of effect of flosequinan on the pharmacokinetics of theophylline.

Authors:  F Kamali; C Edwards; M D Rawlins
Journal:  Br J Clin Pharmacol       Date:  1991-07       Impact factor: 4.335

3.  Effect of mequitazine on the pharmacokinetics of theophylline in asthmatic patients.

Authors:  T Hasegawa; K Takagi; T Kuzuya; M Nadai; R Apichartpichean; I Muraoka
Journal:  Eur J Clin Pharmacol       Date:  1990       Impact factor: 2.953

4.  Effects of alpha-interferon on theophylline pharmacokinetics and metabolism.

Authors:  J H Jonkman; K G Nicholson; P R Farrow; M Eckert; G Grasmeijer; B Oosterhuis; O E De Noord; T W Guentert
Journal:  Br J Clin Pharmacol       Date:  1989-06       Impact factor: 4.335

5.  Effects of gender, AIDS, and acetylator status on intrapulmonary concentrations of isoniazid.

Authors:  John E Conte; Jeffrey A Golden; Mari McQuitty; Juliana Kipps; Sheila Duncan; Elaine McKenna; Elisabeth Zurlinden
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

6.  The effect of tocainide on theophylline metabolism.

Authors:  C M Loi; X Wei; B M Parker; M R Korrapati; R E Vestal
Journal:  Br J Clin Pharmacol       Date:  1993-04       Impact factor: 4.335

7.  Effects of lansoprazole on pharmacokinetics and metabolism of theophylline.

Authors:  T Kokufu; N Ihara; N Sugioka; H Koyama; T Ohta; S Mori; K Nakajima
Journal:  Eur J Clin Pharmacol       Date:  1995       Impact factor: 2.953

Review 8.  Pharmacokinetic drug interactions with theophylline.

Authors:  J H Jonkman; R A Upton
Journal:  Clin Pharmacokinet       Date:  1984 Jul-Aug       Impact factor: 6.447

9.  Theophylline-terbutaline, a steady state study on possible pharmacokinetic interactions with special reference to chronopharmacokinetic aspects.

Authors:  J H Jonkman; L Borgström; W J van der Boon; O E de Noord
Journal:  Br J Clin Pharmacol       Date:  1988-09       Impact factor: 4.335

10.  Pharmacokinetics of theophylline: a dose-range study.

Authors:  V Rovei; F Chanoine; M Strolin Benedetti
Journal:  Br J Clin Pharmacol       Date:  1982-12       Impact factor: 4.335
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