| Literature DB >> 18856063 |
A R Galimov, A A Kruglov, N L Bol'sheva, O Iu Iurkevich, D Ia Lipin'sh, I A Mufazalov, D V Kuprash, S A Nedospasov.
Abstract
Molecular organization, copy number and chromosomal localization of human TNF/LT locus fragment were determined in genomes of two transgenic mouse lines. Genome of the first one contains two copies, organized in head-to-tail manner and determined on eighth chromosome by karyotyping; single transgene copy of the second line is observed on the fifth chromosome. These mice could serve as valuable model for studying both human tumor necrosis factor and lymphotoxin physiological functions.Entities:
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Year: 2008 PMID: 18856063 DOI: 10.1134/s0026893308040201
Source DB: PubMed Journal: Mol Biol (Mosk) ISSN: 0026-8984