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Literature DB >> 18855948

Self-assembling diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and a beta-sheet peptide.

Larisa Cristina Radu¹, Jiyuan Yang, Jindrich Kopecek.

Abstract

The self-assembly of hybrid diblock copolymers composed of poly(HPMA) and beta-sheet peptide P11 (CH(3)CO-QQRFQWQFEQQ-NH(2)) blocks was investigated. Copolymers were synthesized via thiol-maleimide coupling reaction, by conjugation of semitelechelic poly(HPMA)-SH with maleimide-modified beta-sheet peptide. As expected, CD and CR binding studies showed that the peptide block imposed its beta-sheet structural arrangement on the structure of diblock copolymers. TEM and AFM proved that peptide and these copolymers had the ability to self-assemble into fibrils.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2009 PMID： 18855948 PMCID： PMC4599367 DOI： 10.1002/mabi.200800193

Source DB: PubMed Journal: Macromol Biosci ISSN： 1616-5187 Impact factor: 4.979

28 in total

Review 1. Effect of pegylation on pharmaceuticals.

Authors: J Milton Harris; Robert B Chess
Journal: Nat Rev Drug Discov Date: 2003-03 Impact factor: 84.694

2. Structural regulation of a peptide-conjugated graft copolymer: a simple model for amyloid formation.

Authors: Tomoyuki Koga; Kazuhiro Taguchi; Yoshiaki Kobuke; Takatoshi Kinoshita; Masahiro Higuchi
Journal: Chemistry Date: 2003-03-03 Impact factor: 5.236

3. Formation of amyloid fibrils via longitudinal growth of oligomers.

Authors: Puja Shahi; Ritu Sharma; Shefali Sanger; Ish Kumar; Ravinder S Jolly
Journal: Biochemistry Date: 2007-05-31 Impact factor: 3.162

4. Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane.

Authors: S Zhang; T Holmes; C Lockshin; A Rich
Journal: Proc Natl Acad Sci U S A Date: 1993-04-15 Impact factor: 11.205

5. Direct, controlled synthesis of the nonimmunogenic, hydrophilic polymer, poly(N-(2-hydroxypropyl)methacrylamide) via RAFT in aqueous media.

Authors: Charles W Scales; Yulia A Vasilieva; Anthony J Convertine; Andrew B Lowe; Charles L McCormick
Journal: Biomacromolecules Date: 2005 Jul-Aug Impact factor: 6.988

6. Refolding hydrogels self-assembled from N-(2-hydroxypropyl)methacrylamide graft copolymers by antiparallel coiled-coil formation.

Authors: Jiyuan Yang; Chunyu Xu; Chun Wang; Jindrich Kopecek
Journal: Biomacromolecules Date: 2006-04 Impact factor: 6.988

7. Solution self-assembly of hybrid block copolymers containing poly(ethylene glycol) and amphiphilic beta-strand peptide sequences.

Authors: I W Hamley; I A Ansari; V Castelletto; H Nuhn; A Rösler; H-A Klok
Journal: Biomacromolecules Date: 2005 May-Jun Impact factor: 6.988

8. Spectroscopic investigation on gel-forming beta-sheet assemblage of peptide derivatives.

Authors: S Ganesh; S Prakash; R Jayakumar
Journal: Biopolymers Date: 2003-10 Impact factor: 2.505

Review 9. Learning from nature: beta-sheet-mimicking copolymers get organized.

Authors: Hannah M König; Andreas F M Kilbinger
Journal: Angew Chem Int Ed Engl Date: 2007 Impact factor: 15.336

Review 10. Peptide/protein hybrid materials: enhanced control of structure and improved performance through conjugation of biological and synthetic polymers.

Authors: Guido W M Vandermeulen; Harm-Anton Klok
Journal: Macromol Biosci Date: 2004-04-19 Impact factor: 4.979

8 in total

Self-assembling diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and a beta-sheet peptide.

Review 1. Effect of pegylation on pharmaceuticals.

2. Structural regulation of a peptide-conjugated graft copolymer: a simple model for amyloid formation.

3. Formation of amyloid fibrils via longitudinal growth of oligomers.

4. Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane.

5. Direct, controlled synthesis of the nonimmunogenic, hydrophilic polymer, poly(N-(2-hydroxypropyl)methacrylamide) via RAFT in aqueous media.

6. Refolding hydrogels self-assembled from N-(2-hydroxypropyl)methacrylamide graft copolymers by antiparallel coiled-coil formation.

7. Solution self-assembly of hybrid block copolymers containing poly(ethylene glycol) and amphiphilic beta-strand peptide sequences.

8. Spectroscopic investigation on gel-forming beta-sheet assemblage of peptide derivatives.

Review 9. Learning from nature: beta-sheet-mimicking copolymers get organized.

Review 10. Peptide/protein hybrid materials: enhanced control of structure and improved performance through conjugation of biological and synthetic polymers.

Review 1. Smart self-assembled hybrid hydrogel biomaterials.

2. Self-assembled hydrogels from poly[N-(2-hydroxypropyl)methacrylamide] grafted with beta-sheet peptides.

Review 3. Peptide-directed self-assembly of hydrogels.

Review 4. Protein- and peptide-modified synthetic polymeric biomaterials.

5. HYDROGELS FROM SOFT CONTACT LENSES AND IMPLANTS TO SELF-ASSEMBLED NANOMATERIALS.

6. HPMA copolymers: origins, early developments, present, and future.

7. Modification of β-Sheet Forming Peptide Hydrophobic Face: Effect on Self-Assembly and Gelation.

8. Self-Healing, Self-Assembled β-Sheet Peptide-Poly(γ-glutamic acid) Hybrid Hydrogels.