Literature DB >> 18855481

Enantiomeric discorhabdin alkaloids and establishment of their absolute configurations using theoretical calculations of electronic circular dichroism spectra.

Tanja Grkovic1, Yuanqing Ding, Xing-Cong Li, Victoria L Webb, Daneel Ferreira, Brent R Copp.   

Abstract

Enantiomeric pairs of the cytotoxic pyrroloiminoquinone marine alkaloids discorhabdins B (2), G*/I (3), L (4), and W (5) have been isolated from Latrunculia species sponges collected at different locations around the coast of New Zealand. The absolute configuration of all compounds was secured by comparison of observed data with the results of time-dependent density functional theory (TDDFT) calculations of electronic circular dichroism (ECD) spectra. Enantiomeric discorhabdins exhibit equipotent antiproliferative biological activity.

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Year:  2008        PMID： 18855481     DOI： 10.1021/jo801622n

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  9 in total

1.  Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia.

Authors:  Minkyun Na; Yuanqing Ding; Bin Wang; Babu L Tekwani; Raymond F Schinazi; Scott Franzblau; Michelle Kelly; Robert Stone; Xing-Cong Li; Daneel Ferreira; Mark T Hamann
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

Review 2.  Microscale methodology for structure elucidation of natural products.

Authors:  Tadeusz F Molinski
Journal:  Curr Opin Biotechnol       Date:  2010-09-27       Impact factor: 9.740

3.  Puupehanol, a sesquiterpene-dihydroquinone derivative from the marine sponge Hyrtios sp.

Authors:  Wen-Hui Xu; Yuanqing Ding; Melissa R Jacob; Ameeta K Agarwal; Alice M Clark; Daneel Ferreira; Zong-Suo Liang; Xing-Cong Li
Journal:  Bioorg Med Chem Lett       Date:  2009-09-11       Impact factor: 2.823

4.  Determination of Absolute Configuration of Natural Products: Theoretical Calculation of Electronic Circular Dichroism as a Tool.

Authors:  Xing-Cong Li; Daneel Ferreira; Yuanqing Ding
Journal:  Curr Org Chem       Date:  2010-10-01       Impact factor: 2.180

5.  Relative and absolute stereochemistry of diacarperoxides: antimalarial norditerpene endoperoxides from marine sponge Diacarnus megaspinorhabdosa.

Authors:  Fan Yang; Yike Zou; Ru-Ping Wang; Mark T Hamann; Hong-Jun Zhang; Wei-Hua Jiao; Bing-Nan Han; Shao-Jiang Song; Hou-Wen Lin
Journal:  Mar Drugs       Date:  2014-08-08       Impact factor: 5.118

6.  New Discorhabdin B Dimers with Anticancer Activity from the Antarctic Deep-Sea Sponge Latrunculia biformis.

Authors:  Fengjie Li; Dorte Janussen; Deniz Tasdemir
Journal:  Mar Drugs       Date:  2020-02-11       Impact factor: 5.118

Review 7.  Chemistry, Chemotaxonomy and Biological Activity of the Latrunculid Sponges (Order Poecilosclerida, Family Latrunculiidae).

Authors:  Fengjie Li; Michelle Kelly; Deniz Tasdemir
Journal:  Mar Drugs       Date:  2021-01-09       Impact factor: 5.118

8.  Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge.

Authors:  Jae Sung Park; Eunji Cho; Ji-Yeon Hwang; Sung Chul Park; Beomkoo Chung; Oh-Seok Kwon; Chung J Sim; Dong-Chan Oh; Ki-Bong Oh; Jongheon Shin
Journal:  Mar Drugs       Date:  2020-12-23       Impact factor: 5.118

9.  Targeted Isolation of Tsitsikammamines from the Antarctic Deep-Sea Sponge Latrunculia biformis by Molecular Networking and Anticancer Activity.

Authors:  Fengjie Li; Dorte Janussen; Christian Peifer; Ignacio Pérez-Victoria; Deniz Tasdemir
Journal:  Mar Drugs       Date:  2018-08-02       Impact factor: 5.118
  9 in total

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