OBJECTIVE: To review the role of hybrid positron emission tomography (PET)-computed tomography (CT) systems in the design and management of cancer patients in the modern radiation oncology practice. PET is co-registered with CT and incorporated into a systematic approach to the staging, management, and assessment of response and surveillance of a variety of oncologic diagnoses. METHODS: A review of the literature of functional imaging such as PET-CT in staging, treatment plan design, assessment of response and detection of recurrence for tumors involving the head and neck, lung, esophagus, rectum amongst others. RESULTS: PET and PET-CT offer significant advantages which include more accurate staging which often results in management changes in roughly one-third of patients across a number of disease site. More accurate target definition may augment highly conformal radiation treatment plans using intensity-modulated radiation therapy and stereotactic radiosurgery and radiotherapy. CONCLUSION: The emerging data appears to suggest the functional imaging may be a more useful tool to evaluate the therapeutic effect of treatment, detect early failures and prognosticate long-term outcome.
OBJECTIVE: To review the role of hybrid positron emission tomography (PET)-computed tomography (CT) systems in the design and management of cancerpatients in the modern radiation oncology practice. PET is co-registered with CT and incorporated into a systematic approach to the staging, management, and assessment of response and surveillance of a variety of oncologic diagnoses. METHODS: A review of the literature of functional imaging such as PET-CT in staging, treatment plan design, assessment of response and detection of recurrence for tumors involving the head and neck, lung, esophagus, rectum amongst others. RESULTS: PET and PET-CT offer significant advantages which include more accurate staging which often results in management changes in roughly one-third of patients across a number of disease site. More accurate target definition may augment highly conformal radiation treatment plans using intensity-modulated radiation therapy and stereotactic radiosurgery and radiotherapy. CONCLUSION: The emerging data appears to suggest the functional imaging may be a more useful tool to evaluate the therapeutic effect of treatment, detect early failures and prognosticate long-term outcome.
Authors: Mathieu Hatt; John A Lee; Charles R Schmidtlein; Issam El Naqa; Curtis Caldwell; Elisabetta De Bernardi; Wei Lu; Shiva Das; Xavier Geets; Vincent Gregoire; Robert Jeraj; Michael P MacManus; Osama R Mawlawi; Ursula Nestle; Andrei B Pugachev; Heiko Schöder; Tony Shepherd; Emiliano Spezi; Dimitris Visvikis; Habib Zaidi; Assen S Kirov Journal: Med Phys Date: 2017-05-18 Impact factor: 4.071
Authors: Sarmad Siddiqui; Stephen Kadlecek; Mehrdad Pourfathi; Yi Xin; William Mannherz; Hooman Hamedani; Nicholas Drachman; Kai Ruppert; Justin Clapp; Rahim Rizi Journal: Adv Drug Deliv Rev Date: 2016-09-04 Impact factor: 15.470
Authors: Michael R Folkert; Jeremy Setton; Aditya P Apte; Milan Grkovski; Robert J Young; Heiko Schöder; Wade L Thorstad; Nancy Y Lee; Joseph O Deasy; Jung Hun Oh Journal: Phys Med Biol Date: 2017-06-12 Impact factor: 3.609
Authors: Ilwoo Park; Peder E Z Larson; Matthew L Zierhut; Simon Hu; Robert Bok; Tomoko Ozawa; John Kurhanewicz; Daniel B Vigneron; Scott R Vandenberg; C David James; Sarah J Nelson Journal: Neuro Oncol Date: 2010-01-25 Impact factor: 12.300
Authors: Seong-Jang Kim; Sang-Hyun Hwang; In Joo Kim; Min Ki Lee; Chang Hun Lee; Sang-Yull Lee; Eun Yup Lee Journal: J Exp Clin Cancer Res Date: 2010-06-12
Authors: Valentina Bravatà; Alessandro Stefano; Francesco P Cammarata; Luigi Minafra; Giorgio Russo; Stefania Nicolosi; Sabina Pulizzi; Cecilia Gelfi; Maria C Gilardi; Cristina Messa Journal: J Exp Clin Cancer Res Date: 2013-04-30