BACKGROUND: Despite nutritional intervention, albumin concentrations are often low in critically ill premature neonates. OBJECTIVE: Our aim was to quantify albumin synthesis rates during early life under physiologic circumstances. Human fetuses thereby reflect the developmentally related optimal condition. DESIGN: Pregnant women undergoing elective cesarean delivery received 3 different labeled amino acid infusions starting at different times before surgery. With the use of mass spectrometry techniques, this novel model enabled us to quantify fetal albumin synthesis from a single blood sample taken from the umbilical cord after cesarean delivery. The fractional synthesis rate reflects the fraction of the albumin pool that is daily renewed. The absolute synthesis rate is the absolute amount of albumin that is daily synthesized. Results are expressed as medians (25th-75th percentile). RESULTS: We studied 8 fetuses at 29.9 (28.4-35.4) weeks of gestation and 8 fetuses around term. Fractional synthesis rates in premature fetuses [17.5 (12.1-24.4) %/d] were higher (P = 0.02) than in mature fetuses [10.4 (9.1-13.7) %/d]. Absolute synthesis rates were also higher (P = 0.02) in premature than in mature fetuses: 280 (227-365) versus 205 (184-238) mg . kg(-1) . d(-1). CONCLUSIONS: On a weight basis, albumin synthesis rates in premature fetuses were higher than in fetuses at term and were higher than the rates previously found in neonates after preterm birth. Considering that the premature fetal liver can synthesize albumin at a high rate, the observed hypoalbuminemia in premature infants therefore seems to suggest that current (nutritional) therapies fail to meet requirements necessary to sustain optimum albumin synthesis rates.
BACKGROUND: Despite nutritional intervention, albumin concentrations are often low in critically ill premature neonates. OBJECTIVE: Our aim was to quantify albumin synthesis rates during early life under physiologic circumstances. Human fetuses thereby reflect the developmentally related optimal condition. DESIGN: Pregnant women undergoing elective cesarean delivery received 3 different labeled amino acid infusions starting at different times before surgery. With the use of mass spectrometry techniques, this novel model enabled us to quantify fetal albumin synthesis from a single blood sample taken from the umbilical cord after cesarean delivery. The fractional synthesis rate reflects the fraction of the albumin pool that is daily renewed. The absolute synthesis rate is the absolute amount of albumin that is daily synthesized. Results are expressed as medians (25th-75th percentile). RESULTS: We studied 8 fetuses at 29.9 (28.4-35.4) weeks of gestation and 8 fetuses around term. Fractional synthesis rates in premature fetuses [17.5 (12.1-24.4) %/d] were higher (P = 0.02) than in mature fetuses [10.4 (9.1-13.7) %/d]. Absolute synthesis rates were also higher (P = 0.02) in premature than in mature fetuses: 280 (227-365) versus 205 (184-238) mg . kg(-1) . d(-1). CONCLUSIONS: On a weight basis, albumin synthesis rates in premature fetuses were higher than in fetuses at term and were higher than the rates previously found in neonates after preterm birth. Considering that the premature fetal liver can synthesize albumin at a high rate, the observed hypoalbuminemia in premature infants therefore seems to suggest that current (nutritional) therapies fail to meet requirements necessary to sustain optimum albumin synthesis rates.
Authors: Stein Schalkwijk; Aaron O Buaben; Jolien J M Freriksen; Angela P Colbers; David M Burger; Rick Greupink; Frans G M Russel Journal: Clin Pharmacokinet Date: 2018-06 Impact factor: 6.447
Authors: Cyntia B Manzano-Salgado; Maribel Casas; Maria-Jose Lopez-Espinosa; Ferran Ballester; Carmen Iñiguez; David Martinez; Dora Romaguera; Silvia Fernández-Barrés; Loreto Santa-Marina; Mikel Basterretxea; Thomas Schettgen; Damaskini Valvi; Jesus Vioque; Jordi Sunyer; Martine Vrijheid Journal: Environ Health Perspect Date: 2017-09-20 Impact factor: 9.031
Authors: Kristien E C Bouter; Erik J M van Bommel; Hans Jansen; Dewi van Harskamp; Henk Schierbeek; Mariëtte T Ackermans; Mireille J Serlie; Alinda W M Schimmel; Max Nieuwdorp; Geesje M Dallinga-Thie; Daniël H van Raalte Journal: Diabetes Obes Metab Date: 2020-02-27 Impact factor: 6.577
Authors: Apeksha Pathak; R Siddalingesha; Kamal N Prasad; Nibha Kamal; Archana Sinha; Ananya Ghosh; Bhuwan K Singh; Pankaj Kumar; R Surekha Journal: J Family Med Prim Care Date: 2022-06-30
Authors: Carmen Unzu; Marc Friedli; Alexis Bosman; Marisa E Jaconi; Barbara E Wildhaber; Anne-Laure Rougemont Journal: Stem Cells Int Date: 2016-01-06 Impact factor: 5.443
Authors: Laurens F Reeskamp; John S Millar; Liya Wu; Hans Jansen; Dewi van Harskamp; Henk Schierbeek; Daniel A Gipe; Daniel J Rader; Geesje M Dallinga-Thie; G Kees Hovingh; Marina Cuchel Journal: Arterioscler Thromb Vasc Biol Date: 2021-03-11 Impact factor: 8.311