Shimpei Niwa1,2, Hidetoshi Mezawa1,3, Naoaki Kobayashi3,4, Hiroyuki Ida3, Mitsuyoshi Urashima1,3. 1. Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. 2. Safety and Risk Management Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan. 3. Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan. 4. Department of Pediatrics, Shiomidai Hospital, Yokohama, Japan.
Abstract
BACKGROUND: Because vitamin D may have beneficial effects on glucose metabolism in pregnant women with gestational diabetes mellitus, we explored whether maternal 25-hydroxyvitamin D (25OHD) levels in normal pregnancy have association with diabetes-related hormone levels and glycated albumin (GA). METHODS: A prospective cohort study was performed to collect serum samples from 612 pairs of pregnant women and cord blood of their offspring. Levels of 25OHD and GA in maternal and cord blood were measured by radioimmunoassay and enzyme assay, respectively. Using cord serum, 12 diabetes-related hormones were assayed. Spearman's rank correlation coefficient was used to quantify the strength of association between biomarkers. RESULTS: A prominent association between maternal and cord 25OHD levels (r = 0.76, 95% confidence intervals (CIs): 0.73-0.79, P < 0.0001) and weak association between maternal and cord GA (r = 0.22, 95% CIs: 0.14-0.30, P < 0.0001) were shown. Among the 12 diabetes-related hormones, both maternal and cord 25OHD levels showed prominent negative associations with glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). CONCLUSIONS: These results suggest that decreased maternal 25OHD may be associated with decreased cord 25OHD and increased cord GLP-1 and GIP levels, which may be involved with the transfer of maternal glucose to the fetus.
BACKGROUND: Because vitamin D may have beneficial effects on glucose metabolism in pregnant women with gestational diabetes mellitus, we explored whether maternal 25-hydroxyvitamin D (25OHD) levels in normal pregnancy have association with diabetes-related hormone levels and glycated albumin (GA). METHODS: A prospective cohort study was performed to collect serum samples from 612 pairs of pregnant women and cord blood of their offspring. Levels of 25OHD and GA in maternal and cord blood were measured by radioimmunoassay and enzyme assay, respectively. Using cord serum, 12 diabetes-related hormones were assayed. Spearman's rank correlation coefficient was used to quantify the strength of association between biomarkers. RESULTS: A prominent association between maternal and cord 25OHD levels (r = 0.76, 95% confidence intervals (CIs): 0.73-0.79, P < 0.0001) and weak association between maternal and cord GA (r = 0.22, 95% CIs: 0.14-0.30, P < 0.0001) were shown. Among the 12 diabetes-related hormones, both maternal and cord 25OHD levels showed prominent negative associations with glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). CONCLUSIONS: These results suggest that decreased maternal 25OHD may be associated with decreased cord 25OHD and increased cord GLP-1 and GIP levels, which may be involved with the transfer of maternal glucose to the fetus.
Authors: F Strobel; J Reusch; M Penna-Martinez; E Ramos-Lopez; E Klahold; C Klepzig; J Wehrle; H Kahles; K Badenhoop Journal: Horm Metab Res Date: 2013-11-06 Impact factor: 2.936
Authors: Chris H P van den Akker; Henk Schierbeek; Trinet Rietveld; Andras Vermes; Johannes J Duvekot; Eric A P Steegers; Johannes B van Goudoever Journal: Am J Clin Nutr Date: 2008-10 Impact factor: 7.045