| Literature DB >> 18839952 |
Baodui Wang1, Chenjie Xu, Jin Xie, Zhengyin Yang, Shouheng Sun.
Abstract
We report a new strategy for coupling chromone to Fe3O4 nanoparticles. The chromone-Fe3O4 NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 microg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe3O4 conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe3O4 NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications.Entities:
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Year: 2008 PMID: 18839952 PMCID: PMC2584374 DOI: 10.1021/ja806519m
Source DB: PubMed Journal: J Am Chem Soc ISSN: 0002-7863 Impact factor: 15.419