Literature DB >> 18839952

pH controlled release of chromone from chromone-Fe3O4 nanoparticles.

Baodui Wang1, Chenjie Xu, Jin Xie, Zhengyin Yang, Shouheng Sun.   

Abstract

We report a new strategy for coupling chromone to Fe3O4 nanoparticles. The chromone-Fe3O4 NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 microg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe3O4 conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe3O4 NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications.

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Year:  2008        PMID: 18839952      PMCID: PMC2584374          DOI: 10.1021/ja806519m

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN: 0002-7863            Impact factor:   15.419


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