| Literature DB >> 18836457 |
Benjamin A Flusberg1, Axel Nimmerjahn, Eric D Cocker, Eran A Mukamel, Robert P J Barretto, Tony H Ko, Laurie D Burns, Juergen C Jung, Mark J Schnitzer.
Abstract
A central goal in biomedicine is to explain organismic behavior in terms of causal cellular processes. However, concurrent observation of mammalian behavior and underlying cellular dynamics has been a longstanding challenge. We describe a miniaturized (1.1 g mass) epifluorescence microscope for cellular-level brain imaging in freely moving mice, and its application to imaging microcirculation and neuronal Ca(2+) dynamics.Entities:
Mesh:
Year: 2008 PMID: 18836457 PMCID: PMC2828344 DOI: 10.1038/nmeth.1256
Source DB: PubMed Journal: Nat Methods ISSN: 1548-7091 Impact factor: 28.547